42 -7 (57) 2023 — Kasymov A.L., Sadikov R.A. — POSSIBILITIES OF PHLEGMON OF PELVIS FORMATION IN RATS AND WITH THE USE OF AN EXPERIMENTAL MODEL OF DIABETIC NEW METHODS OF TREATMENT

POSSIBILITIES OF PHLEGMON OF PELVIS FORMATION IN RATS AND WITH THE USE OF AN EXPERIMENTAL MODEL OF DIABETIC NEW METHODS OF TREATMENT

Kasymov A.L., Andijan State Medical Institute Uzbekistan, Experimental laboratory of the Republican Specialized Scientific and Practical Medical Center for Surgery named after academician V.V.Vakhidov Uzbekistan

Sadikov R.A., Andijan State Medical Institute Uzbekistan, Experimental laboratory of the Republican Specialized Scientific and Practical Medical Center for Surgery named after academician V.V.Vakhidov Uzbekistan

Juraev G.G., Andijan State Medical Institute Uzbekistan, Experimental laboratory of the Republican Specialized Scientific and Practical Medical Center for Surgery named after academician V.V.Vakhidov Uzbekistan

Soliyev M.B. Andijan State Medical Institute Uzbekistan, Experimental laboratory of the Republican Specialized Scientific and Practical Medical Center for Surgery named after academician V.V.Vakhidov Uzbekistan

Resume

The article presents the results of experimental studies on the possibility of the formation of a purulent

pelvis in laboratory rats and an assessment of the effectiveness of using traditional and new methods of healing. for this purpose, the authors conducted experimental morphological studies on 54 laboratory rats of the “Vistar” breed in the experimental department of the Academician V.V.Vakhidov “RSNPMCH”. A model of diabetic phlegmon of pelvis was used to perform an autopsy of the purulent-necrotic process in rats using photodynamic therapy and laser irradiation. Studies have shown that the use of local laser exposure and photodynamic therapy accelerated the regression of inflammatory infiltration, complete cessation of purulent-necrotic discharge, wound cleansing and activation of regeneration processes.

Keywords: experimental model, diabetic phlegmon, autopsy of the purulent-necrotic process, photosensitization, laser irradiation. the aim of the study is to improve the results of treatment of purulent lesions of the extremities in patients.

First page

250

Last page

259

For citation: Kasymov A.L., Sadikov R.A., Juraev G.G., Soliyev M.B. – POSSIBILITIES OF PHLEGMON OF PELVIS FORMATION IN RATS AND WITH THE USE OF AN EXPERIMENTAL MODEL OF DIABETIC NEW METHODS OF TREATMENT //New Day in Medicine 2023 7(57): 250-259 https://newdaymedicine.com/index.php/2023/07/31/l-286/

LIST OF REFERENCES:

1. Алипов В.В., Аванесян Г.А., Мусаелян А.Г., Алипов А.И., Мустафаева Д.Р. Современные проблемы моделирования и лечения абсцессов мягких тканей. //Хирургия. Журнал им. Н.И. Пирогова. 2020;5:81-87. https://doi.org/10.17116/hirurgia202005181
2. Бабаджанов Б.Д., Матмуротов К.Ж., Атажанов Т.Ш., Саитов Д.Н., Рузметов Н.А. Эффективность селективной внутриартериальной катетерной терапии при лечении диабетической гангрены нижних конечностей // Хирургия Узбекистана 2022;1:102-105.
3. Гертман В.З., Пушкарь Е.С., Пономаренко С.В. Разработка параметров антибактериальной фотодинамичной терапии с использованием света в оптическом диапазоне и фотосенсибилизатора метиленового синего // Актуальні проблеми сучасної медицини: Вісник української медичної стоматологічної академії. 2017;3(59).
4. Завалий И.П. Экспериментально-клиническое исследование состояния и лечение гнойных ран при сахарном диабете // Вестник новгородского государственного университета – 2016;1(92):32-36.
5. Пушкарь Ю.Ю., Бадиков Д.В. Исследование влияния низкоинтенсивного лазерного излучения на динамику течения раневого процесса // Научный Вестник Здравоохранения Кубани – 2020;5(71):11-20.
6. Студеникин А.В., Стадников А.А., Нузова О.Б., Колосова Н.И. Особенности течения раневого процесса у крыс на фоне аллоксанового диабета при различных способах местного лечения //Пермский медицинский журнал. 2016;33(20:98-103. doi: 10.17816/pmj33298-103
7. Amos-Tautua BM, Songca SP, Oluwafemi OS. Application of porphyrins in antibacterial photodynamic therapy. //Molecules. 2019;24:24-56.
8. Brandão Mg.Sa., Ximenes Ma.M., Sousa D.F, Veras V.S., Barros L.M., Rabeh Sa.N., Costa I.G., Araújo T.M. Photodynamic therapy for infected foot ulcers in people with diabetes mellitus: a systematic review. //Sao Paulo Med J. 2023 May 12;141(6):e2022476.
9. Li C, Jia X, Bian Y, Qi D, Wu J. Different susceptibility of spores and hyphae of Trichophyton rubrum to methylene blue mediated photodynamic treatment in vitro. Mycoses. 2021;64:48-54. 10.1111/myc.13182
10. Ning X, He G, Zeng W, Xia Y. The photosensitizer-based therapies enhance the repairing of skin wounds. Front Med (Lausanne). 2022 Aug 11;9:915548.