44 -7 (57) 2023 — Abdulloev M.Z., Oblokulov A.R. — ANALYSIS OF THE RESULTS OF THE STUDY ON THE DETERMINATION OF CYTOKINES IN PATIENTS WITH CHRONIC HEPATITIS C DEPENDING ON THE PRESENCE OF CRIGLOBULINEMIA

ANALYSIS OF THE RESULTS OF THE STUDY ON THE DETERMINATION OF CYTOKINES IN PATIENTS WITH CHRONIC HEPATITIS C DEPENDING ON THE PRESENCE OF CRIGLOBULINEMIA

Abdulloev M.Z., Bukhara State Medical Institute named after Abu Ali ibn Sino

Oblokulov A.R. Bukhara State Medical Institute named after Abu Ali ibn Sino

Resume

40 patients with CHC with extrahepatic manifestations were involved in the conducted studies to determine the cytokines IL-10 and IL-18 in patients with CHC, depending on the presence of cryglobulinemia. The results of the study showed that in patients with chronic hepatitis C with extrahepatic manifestations, the anti-inflammatory cytokine IL-10 was reduced by 2.37 times in patients, and there was a significant increase in the content of pro-inflammatory cytokine IL-18 in the blood serum by 2.71 times in relation to normal values.

Key words: chronic hepatitis C, extrahepatic manifestations, cryoglobulin, interleukin, cytokine.

First page

265

Last page

269

For citation: Abdulloev M.Z., Oblokulov A.R. – ANALYSIS OF THE RESULTS OF THE STUDY ON THE DETERMINATION OF CYTOKINES IN PATIENTS WITH CHRONIC HEPATITIS C DEPENDING ON THE PRESENCE OF CRIGLOBULINEMIA //New Day in Medicine 2023 7(57): 265-269 https://newdaymedicine.com/index.php/2023/08/01/l-288/

LIST OF REFERENCES:

1. Облокулова З.И., Нуралиев Н.А. Клинико-диагностическая характеристика фиброзообразования печени у больных с хроническим вирусным гепатитом с с внепеченочнымы проявлениями //Тиббиётда янги кун. – Ташкент. – 2022;10(48):343-347(14.00.00; №22).
2. Domont F., Cacoub P. Chronic hepatitis C virus infection, a new cardiovascular risk factor? //Liver International. 2016;36(5):621-627.
3. Oblokulova Z. I., Nuraliyev N. A., Oblokulov A. R. Study and analysis of the cytokine status and features of the distribution of genotypes and alleles of the polymorphous locus of the interleukin-10 gene in patients with viral hepatitis c with extrahepative manifestations //Science Asia – Journal of The Science Society of Thailand. 2022;48(6):1085-1090.
4. Cacoub P. et al. Extrahepatic manifestations of chronic hepatitis C virus infection //Therapeutic advances in infectious disease. 2016;3(1):3-14.
5. Martinello M. et al. Management of acute HCV infection in the era of direct-acting antiviral therapy //Nature reviews Gastroenterology hepatology. 2018;15(7):412-424.
6. Oblokulova Z.I., Oblokulov A.R., Elmuradova A.A., Farmanova M.A. Virologic response in the treatment of infection with antiviral drugs //World Journal of Pharmaceutical Research. 2022;9(9):87-92.
7. Malkov P.G., Danilova N.V., Moskvina L.V. Extrahepatic manifestations of chronic hepatitis c (a review). //Fundamental research. 2009;5:41-46. (in Russ.).
8. Дунаева Н.В., Эсауленко Е.В. Криоглобулинемия и вирус гепатита С. //Журнал инфектологии. 2011;3(2):15-20.
9. Carrat F. et al. Clinical outcomes in patients with chronic hepatitis C after direct-acting antiviral treatment: a prospective cohort study //The Lancet. 2019;393(10179):1453-1464.
10. Булатова И.А. Цитокины у больных циррозом печени вирусного и невирусного генеза // Новости «Вектор-Бест». 2015;1(75):2-5.
11. Балашова А.А. Цитокины и алкогольная болезнь печени //Клиническая фармакология и терапия. 2017;26(1):41-46.
12. Рузибакиева М.Р., Арипова Т.У., Хаджибаев Ф.А., и др. Применение генотипирования полиморфизма cyp3a5 для коректировки дозы такролимуса при трансплантации почки //Российский иммунологический журнал. 2019;22(2-1):499-502.
13. Гончарова И.А. Эффект полиморфизма генов IL10 (rs1800872) и CXCL10 (rs4386624, rs4256246) в развитии инфекционных заболеваний вирусной и бактериальной природы //Научные результаты биомедицинских исследований. 2019;5(4):32-43.
14. Sghaier I. et al. Genetic variants in IL-6 and IL-10 genes and susceptibility to hepatocellular carcinoma in HCV infected patients //Cytokine. 2017;89:62-67.