13 -8 (58) 2023 — Ganieva Sh.Sh. — IMMUNO-INFLAMMATORY MARKERS OF REMODELING OF THE LEFT VENTRICLE OF THE HEART IN ISCHEMIC HEART DISEASE

IMMUNO-INFLAMMATORY MARKERS OF REMODELING OF THE LEFT VENTRICLE OF THE HEART IN ISCHEMIC HEART DISEASE

Ganieva Sh.Sh. Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

In the article, the author studied the factors of endothelial damage in hypertension and coronary heart disease, which constitute cardiovascular syntropy. Cytokines that are markers of endothelial dysfunction are IGF-I, VEGF, TGF-β1 and procalcitonin of the blood serum.The study found that patients with elevated VEGF levels have a high risk of developing and progressing cardiovascular pathology, namely fibrosclerosis and myocardial hypertrophy on the background of arterial hypertension, regardless of its severity.  Keywords: cardiovascular diseases, coronary heart disease, arterial hypertension, cytokines, immunological markers

First page

74

Last page

80

For citation: Ganieva Sh.Sh. – IMMUNO-INFLAMMATORY MARKERS OF REMODELING OF THE LEFT VENTRICLE OF THE HEART IN ISCHEMIC HEART DISEASE //New Day in Medicien 2023 8(58): 74-80 https://newdaymedicine.com/index.php/2023/08/08/l-301/

LIST OF REFERENCES:

1. Галиханова Л.И., Сагадеева Э.Г., Муталова Э.Г. (2019). Ремоделирование сердца у молодых женщин с ожирением. //Медицинский вестник Башкортостана, 2019;14(3 (81):9-15.
2. Кубарева М.И., Ибатов А.Д. Психосоциальные факторы и ишемическая болезнь сердца //Терапевтический архив. 2019;12. URL: https://cyberleninka.ru/article/n/psihosotsialnye-faktory-i-ishemicheskaya-bolezn-serdtsa
3. Лебедева И.А., Маградзе Г.Н., Парцерняк С.А., Устюжанинов В.С., Парцерняк А.С., Айвазян Б.Г., Афлитонов М.А. (2021). Общность патогенеза сердечно-сосудистых заболеваний и воспалительных процессов полости рта и челюстно-лицевой области с позиций взаимосвязи системных провоспалительных биомаркеров. //Кардиология: Новости. Мнения. Обучение, 2021;1(26):39-48.
4. Максимов М.Л., Кулагина Л.Ю., Кадысева Э.Р., Исмаилова М.А., Звегинцева А.А. Витаминотерапия и витаминопрофилактика сердечно-сосудистых заболеваний //Sciences of Europe. 2020;58/2(58). URL: https://cyberleninka.ru/article/n/vitaminoterapiya-i-vitaminoprofilaktika-serdechno-sosudistyh-zabolevaniy
5. Calvillo L, Gironacci M.M., Crotti L, Meroni P.L, Parati G. Neuroimmune crosstalk in the pathophysiology of hypertension. //Nat Rev Cardiol. 2019 Aug;16(8):476-490. https://doi.org/10.1038/s41569-019-0178-1. PMID: 30894678.
6. Gay I.C., Tran D.T., Cavender A.C., Weltman R., Chang J., Luckenbach E. et al. The effect of periodontal therapy on glycemic control in a hispanic population with type 2 diabetes: a randomized controlled trial //J. Clin. Periodontol. 2014;41:673-680.
7. Lorente L, Martín MM, Pérez-Cejas A, et al. Non-survivor septic patients have persistently higher serum sCD40L levels than survivors. //J Crit Care. 2017;41:177-82. https://doi.org/10.1016/j.jcrc.2017.05.021.
8. Majeed B, Tawinwung S, Eberson LS, Secomb TW, Larmonier N, Larson DF: Interleukin-2/anti-interleukin-2 immune complex expands regulatory T cells and reduces angiotensin II-induced aortic stiffening. //Int J Hypertens 2014;12:63-65, 2014 [PMC free article] [PubMed] [Google Scholar]