16 -9 (59) 2023 — Abdulkhakimov Sh.A. — CHRONIC KIDNEY DISEASE LEADS TO DISRUPTION OF TIGHT JUNCTIONS IN THE GASTRIC AND SMALL INTESTINAL EPITHELIUM

CHRONIC KIDNEY DISEASE LEADS TO DISRUPTION OF TIGHT JUNCTIONS IN THE GASTRIC AND SMALL INTESTINAL EPITHELIUM

Abdulkhakimov Sh.A. Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Maintaining the integrity of tight junctions (TJs), which act as a barrier between the cells of the gastrointestinal lining, is crucial for preventing the infiltration of microbial toxins, antigens, and harmful substances into the underlying tissues and the internal environment. The capacity to absorb these substances underscores the significance of an intact intestinal epithelial barrier; its compromise can result in both local and systemic inflammation. Recently, we identified a decrease in essential protein components of colonic epithelial TJs in animals affected by chronic kidney disease (CKD). Autopsy investigations have unveiled a consistent presence of inflammation throughout the gastrointestinal tract in individuals with uremia. This evidence implies that the disruption of the epithelial barrier across all segments of the gastrointestinal tract, encompassing the stomach, jejunum, and ileum, might be induced by uremia. The current research was initiated to delve into this potential phenomenon.

Key words: Gastritis · Enterocolitis · Inflammation · Malnutrition ·End-stage renal disease · Uremia

First page

81

Last page

85

For citation: Abdulkhakimov Sh.A. – CHRONIC KIDNEY DISEASE LEADS TO DISRUPTION OF TIGHT JUNCTIONS IN THE GASTRIC AND SMALL INTESTINAL EPITHELIUM //New Day in Medicine 2023 9(59): 81-85 https://newdaymedicine.com/index.php/2023/09/06/l-354/

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