57 -10 (60) 2023 — Zhuraeva G.B. — METHODS FOR IMPROVING MORPHOLOGICAL DIAGNOSIS IN ENDOMETRISIS

METHODS FOR IMPROVING MORPHOLOGICAL DIAGNOSIS IN ENDOMETRISIS

Zhuraeva G.B. Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

In this article, the level of expression of estrogen (ER-α) and progesterone (PR-α) receptors in both glandular epithelial and stromal structures was investigated in ovarian endometriosis. As material, ovarian tissue from 28 patients was examined by immunohistochemical method. According to the results of immunohistochemical examination of ovarian endometriosis, the expression of estrogen (ER-α) and progesterone (PR-α) receptors in both epithelial cells and stromal structures, the sensitivity of these tissue structures to hormones during the development of endometriosis, and the appearance of special protein-containing receptors are different. indicates that it is at the level The higher expression level of ER-α receptor compared to PR-α receptor in epithelial cells that have become endometriotic glands compared to stromal structures indicates that the role of estrogen hormone is highly significant in the mechanism of endometriosis development.

Key words: ovary, endometriosis, immunohistochemistry, estrogen, progesterone, ER-α, PR-α receptors

First page

336

Last page

341

For citation: Zhuraeva G.B. – METHODS FOR IMPROVING MORPHOLOGICAL DIAGNOSIS IN ENDOMETRISIS //New Day in Medicine 2023 10(60): 336-341 https://newdaymedicine.com/index.php/2023/10/10/l-445/

LIST OF REFERENCES:

  1. Аничков Н.М., Печеникова В.А., Костючек Д.Ф. Клинико-морфологические особенности эндометриоидной болезни: аденомиоза, эндометриоза яичников, экстрагениталного эндометриоза. // Архив патологии 2011;4;С.-5-10.
  2. Баскаков В.П., Цвелев Ю.В. Кира Е.Ф. Эндометриоидная болезнь. // СПб: Нева-Люкс 2002; 452.
  3. Kaspar H.G., Crum C.P. The utility of immunohistochemistry in the differential diagnosis of gynecologic disorders // Arch. Pathol. Lab. Med. 2015; 139(1):39-54.
  4. Juraeva G.B. Study of clinical and morfological features of differentforms of endomtrioisis // Nat.Volatiles @ Essent.Oils. 2021; 4:10901–10907.
  5. Joraeva G.B., Isroilov R.I. Adenomioz va endometriozni turli shakllarining klinik va morfologik xususiyatlarini organish 2021; 8:605-612.
  6. Жураева Г.Б. Изучение клинико- морфологических особенностей разных форм эндометриоза // European Scientific Platform. 2021; 3:50-53. ISBN 978-1-63821-669
  7. Matorras R, Rodríguez F, Pijoan JI, Soto E, Pérez C, Ramón O, et al. Are there any clinical signs and symptoms that are related to endometriosis in infertile women? // Am J Obstet Gynecol. 1996;174:620–3.
  8. Пшеничнюк Е.Ю., Асатурова А.В., Адамян Л.В., Зайцев Н.В. Иммуногистохимические предикторы рецидивирования эндометриоидных кист яичников после лапароскопического оперативного лечения. // Архив патологии. 2018;80(4):14-20.
  9. Rambau P.F. et al. Morphologic reproducibility, genotyping, and immunohistochemical profiling do not support a category of seromucinous carcinoma of the ovary // Am. J. Surg. Pathol. 2017;41(5):685-695.
  10. Matthews J, Wihlén B, Tujague M, Wan J, Ström A, Gustafsson JA. Estrogen receptor (ER) beta modulates ERalpha-mediated transcriptional activation by altering the recruitment of c-Fos and c-Jun to estrogen-responsive promoters. // Mol Endocrinol. 2006;20(3):534–543.
  11. Teh WT, McBain J, Rogers P. What is the contribution of embryo-endometrial asynchrony to implantation failure? // J Assist Reprod Genet. 2016;33:1419–1430.
  12. Sharma A, Kumar P. Understanding implantation window, a crucial phenomenon. // J Hum Reprod Sci. 2012;5:2–6.

file

download