142 -10 (60) 2023 — Rakhmatova S.N. — THE RESULTS OF MOLECULAR GENETIC STUDIES IN TIA

THE RESULTS OF MOLECULAR GENETIC STUDIES IN TIA

Rakhmatova S.N. Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Genetic variability may contribute to the risk of stroke through several potential mechanisms. There is growing evidence that genetic studies can help distinguish between subtypes of stroke and even contribute to improving the effectiveness of treatment. When predicting the data presented in Table 5, the result of the prognostic efficacy (AUC) of the VEGF-A polymorphism allele of the rs699947 gene in the main group was 0.58, sensitivity (SE) -0.64, specificity (SP) – 0.42, whereas in patients who had a stroke with TIA and had TIA, but did not have TIA. stroke, these indicators were AUC=0.57, SE=0.66, SP=0.42 and AUC=0.50, se=0.59, SP=0.42 (Table 3.1.23).

Keywords: TIA, VEGF-A of the rs699947 gene, polymorphism allele.

First page

820

Last page

824

For citation: Rakhmatova S.N. – THE RESULTS OF MOLECULAR GENETIC STUDIES IN TIA //New Day in Medicine 2023 10(60): 820-824 https://newdaymedicine.com/index.php/2023/12/27/l-701/

LIST OF REFERENCES:

  1. Vincenti V, Cassano C, Rocchi M, et al. Assignment of the vascular endothelial growth factor gene to human chromosome 6p21.3. // Circulation 1996;93:1493–5.
  2. Greenberg DA, Jin K. Vascular endothelial growth factors (VEGFs) and stroke. // Cell Mol Life Sci 2013;70:1753–61.
  3. Ogunshola OO, Stewart WB, Mihalcik V, et al. VEGF expression correlates with angiogenesis in postnatal developing rat brain. // Dev Brain Res 2000;119:139–53.
  4. Pruissen DM, Kappelle LJ, Rosendaal FR, et al. Genetic association studies in ischemic stroke: replication failure and prospects. // Cerebrovasc Dis 2009;27:290-4.
  5. Shahbazi M., Fryer A.A., Pravica V., Brogan I.J., Ramsay H.M., Hutchinson I.V., Harden P.N. Vascular endothelial growth factor gene polymorphisms are associated with acute renal allograft rejection. // J. Am. Soc. Nephrol. 2002;13:260-264.

file

download