23 -11 (61) 2023 — Rakhmanova N.S., Yakubbekova S.S. — STRUCTURE, EPIDEMIOLOGY, ETIOLOGY AND MORPHOLOGY OF PULMONARY HAMARTOMA

STRUCTURE, EPIDEMIOLOGY, ETIOLOGY AND MORPHOLOGY OF PULMONARY HAMARTOMA

Rakhmanova N.S., Andijan State Medical Institute

Yakubbekova S.S. Andijan State Medical Institute

Resume

The article deals with general concepts, classification, pathogenesis, morphogenesis and pathomorphology of lung hamartoma. Data from the scientific literature of the last 20 years were analyzed. Hamartoma, which is derived from the Greek words hamártēma – error and ónkōma – tumor, is a benign tumor that is mainly mesenchymal tissue that develops congenitally: fat, fibrosis, fat, blood vessels. Hamartomas occur mainly in people aged 25 and older, and on average, in the age range of 40-70 years, men are 2-3 times more common than women. U hamartoma is dysembryogenetic est, in which there is an incorrect development of lung parenchyma tissue, distal part of bronchus and other lung tissues. Lung hamartoma morphologically manifests as hamartochondroma, chondradenoma, lipochondradenoma, myxochondroma, fibrochondroma.

Key words: hamartoma, dysembryogenesis, chondroid, fibromatous, myxomatous, leiomyomatous. Hamartoma.

First page

134

Last page

142

For citation: Rakhmanova N.S., Yakubbekova S.S. – STRUCTURE, EPIDEMIOLOGY, ETIOLOGY AND MORPHOLOGY OF PULMONARY HAMARTOMA //New Day in Medicine 2023 11(61): 134-142 https://newdaymedicine.com/index.php/2023/11/18/l-496/

LIST OF REFERENCES:

1. Visvader J.E. Cells of origin in cancer // Nature. 2011;469(7330):314-322.
2. Blanpain C. Tracing the cellular origin of cancer // Nature Cell Biology. 2013;15(2):126-134.
3. Васильев Н.В., Самцов Е.Н. Гамартома легких: предмет исследования и опыт наблюдения // Сибирский онкологический журнал. 2008;(3).
4. Blair C.T., McElvein R.B. Hamartoma of the Lung // Diseases of the Chest. 1963;44(3):296-302.
5. Tomashefski J.F. Benign endobronchial mesenchymal tumors // The American Journal of Surgical Pathology. 1982;6(6):531-540.
6. Bateson E.M. Histogenesis of intrapulmonary and endobronchial hamartomas and chondromas (cartilage-containing tumours): A hypothesis // The Journal of Pathology. 1970;101(2):77-83.
7. Perez-Atayde A.R., Seiler M.W. Pulmonary hamartoma. An ultrastructural study // Cancer. 1984;53(3):485-492.
8. Fraire A.E., Dail D.H. Mesenchymal tumors, Part II: Tumors of hamartomatous, osteochondromatous, lipomatous, neural, and vascular origin // Dail and Hammar’s Pulmonary Pathology. Springer, New York, NY, 2008;462-499.
9. Fletcher J.A. et al. Cytogenetic and histologic findings in 17 pulmonary chondroid hamartomas: Evidence for a pathogenetic relationship with lipomas and leiomyomas // Genes, Chromosomes and Cancer. 1995;12(3):220-223.
10. van den Bosch J.M. et al. Mesenchymoma of the lung (so called hamartoma): a review of 154 parenchymal and endobronchial cases. // Thorax. 1987;42(10):790-793. 
11. Gjevre J.A., Myers J.L., Prakash U.B.S. Pulmonary Hamartomas // Mayo Clinic Proceedings. 1996;71(1):14-20.
12. McDonald J.R., Harrington S.W., Clagett O.T. Hamartoma (often called chondroma) of the lung // Journal of Thoracic Surgery. 1945;14(2):128-143.
13. King T.C., Myers J. Isolated Metastasis to a Pulmonary Hamartoma // The American Journal of Surgical Pathology. 1995;19(4):472-475.
14. Takemura T. et al. An immunohistochemical study of the mesenchymal and epithelial components of pulmonary chondromatous hamartomas // Pathology International. 1999;49(11):938-946.
15. Bateson E.M. So-called hamartoma of the lung-a true neoplasm of fibrous connective tissue of the bronchi // Cancer. 1973;31(6):1458-1467.
16. Zhang X.T. et al. Peripheral mucous gland adenoma of the lung with parenchymal in vement and smooth muscle in the stroma // Medicine. 2018;97(3):95-97.
17. Takeshima Y., Furukawa K., Inai K. “Adenomyomatous” hamartoma of the lung // Pathology International. 2000;50(12):984-986.
18. Yamada R. et al. An unusual case of pulmonary hamartoma with predominant bronchial mucous glands in the peripheral lung // Pathology International. 2018;68(7):431-435.
19. Itoh H. et al. Solitary fibroleiomyomatous hamartoma of the lung in a patient without a pre-existing smooth-muscle tumor // Pathology International. 2001;51(8):661-665.
20. Kato N. et al. Multiple pulmonary leiomyomatous hamartoma with secondary ossification // Pathology International. 1999;49(3):222-225.