36 -11 (61) 2023 — Babaeva L.A., Khojaeva O.T. — MAIN CAUSES AND FEATURES OF THE CLINICAL COURSE OF GUILLAIN-BARRE SYNDROME IN CHILDREN
MAIN CAUSES AND FEATURES OF THE CLINICAL COURSE OF GUILLAIN-BARRE SYNDROME IN CHILDREN
Babaeva L.A., SEI «Avicenna Tajik state medical university», Dushanbe, Tajikistan
Khojaeva O.T. SEI «Avicenna Tajik state medical university», Dushanbe, Tajikistan
Resume
In 86.7% of cases, HSV-2 (Herpes simplex Virus 2) was detected, in 66.7% – cytomegalovirus infection, in 76.7% – mixed herpes virus infection. The clinical picture was dominated by: peripheral paresis syndrome and areflexia of the lower, less often upper, extremities with preserved sensitivity, pain in the back and lower extremities. No violations of the pelvic organs were noted. The results of tests for the determination of RNA in feces for enteroviruses (PCR) were negative in 100% of cases. 90% of patients had the classic form of GBS. After the treatment, the patients were discharged in a relatively satisfactory condition, followed by rehabilitation. In 10%, the axonal form was observed, accompanied by bulbar symptoms, which led to death.
Keywords: children, acute polyradiculoneuropathy, aetiology, clinic, diagnosis, treatment.
First page
223
Last page
226
For citation: Babaeva L.A., Khojaeva O.T. – MAIN CAUSES AND FEATURES OF THE CLINICAL COURSE OF GUILLAIN-BARRE SYNDROME IN CHILDREN //New Day in Medicine 2023 11(61): 223-226 https://newdaymedicine.com/index.php/2023/11/25/l-519/
LIST OF REFERENCES:
- Пономарев В.В. Редкие неврологические синдромы и болезни. – Санкт- Петербург, 2005.
- Жулев Н.М., Осетров Б.А., Жулев С.Н., Лалаян Т.В. Нейропатии: Руководство для врачей. — СПб: Издательский дом СПбМАПО, 2005.
- Левин О.С. Полиневропатии: клиническое руководство / О.С. Левин. — М.: МИА, 2011.
- Пирадов М.А., Супонева Н.А. «Синдром Гийена-Барре: диагностика и лечение. Руководство для врачей» – 2011.
- Заболевания нервной системы у детей: в 2 т. Т. 2 / под ред. Ж. Айкарди и др.; пер. с англ.; общ. ред. А. А. Скоромца. – М.: Издательство Панфилова; БИНОМ. Лаборатория знаний 2013.
- Величко И.А., Барабанова М.А. Синдром Гийена – Барре как актуальная проблема неврологии. Кубанский научный медицинский вестник. 2019;26(2):150-61. doi: 10.25207/1608-6228-2019-26-2-150-161.
- Супонева Н.А., Шакарян А.К., Рахтеенко А.В. и др. Клинико- лабораторные характеристики, лечение и прогноз синдрома Гийена-Барре у детей. Детские инфекции. 2015;14(3):17-26. doi: 10.22627/2072-81072015-14-3- 17-26.
- Sladky J. T. Guillain-Barre syndrome in children // J. Child Neurol. 2004;19:191-200.
- Legido A., Tenembaum S. N., Katsetos C. D. et al. Autoimmune and postinfectious diseases. Ch. 8. In: Child neurology (Menkes J. H., Sarnat H. B., Maria B. L. eds.). 7 th ed. Philadelphia. Lippincott Williams Wilkins. 2006;557-657.
- Ilyas A. A., Chen Z. W., Cook S. D. et al. Immunoglobulin G subclass distribution of autoantibodies to gangliosides in patients with Guillain-Barre syndrome // Res. Commun. Pathol. Pharmacol. 2002;109:115-123.
- Tsang R. S., Valdivieso-Garcia A. Pathogenesis of Guillain-Barre syndrome // Expert Rev. Anti Infect. Ther. 2003;1:597-608.
- Kieseier B. C., Kiefer R., Gold R. et al. Advances in underswtanding and treatment of immune-mediated disorders of the peripheral nervous system // Muscle Nerve. 2004;30:131-156.
- Magira E. E., Papaijakim M., Nachamkin I. et al. Differential distribution of HLA-DQ beta/DR beta epitopes in the two forms of Guillain-Barre syndrome, acute motor axonal neuropathy and acute inflammatory demyelinating polyneuropatrhy (AIDP); identification of DQ beta epitopes associated with susceptibility to and protection from AIDP // J. Immunol. 2003;170:3074-3080.
- Geleijns K., Schreuder G. M., Jacobs B. C. et al. HLA class II alleles are not a general susceptibility factor in Guillain-Barre syndrome // Neurology. 2005;64:44-49.