45 -11 (61) 2023 — Axmedova N.Sh. — THE SIGNIFICANCE OF GENETIC MUTATIONS IN THE PATHOGENESIS OF THE DEVELOPMENT OF NEPHROPATHY IN CHRONIC KIDNEY DISEASES OF DIFFERENT ETIOLOGIES

THE SIGNIFICANCE OF GENETIC MUTATIONS IN THE PATHOGENESIS OF THE DEVELOPMENT OF NEPHROPATHY IN CHRONIC KIDNEY DISEASES OF DIFFERENT ETIOLOGIES

Axmedova N.Sh.  Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

In modern medicine, a number of scientific studies are being conducted on the significance of genetic predisposition in the development of chronic kidney disease (CKD). This article presents the results of a study conducted to determine the level of APOL1 gene polymorphism in the pathogenesis of nephropathies of various etiologies among the Uzbek population. The analysis showed that among the patients included in the study, the presence of G1 and G2 polymorphism mutations of the APOL1 gene was detected.

Key words: Chronic kidney diseases of various etiologies, the importance of genetic mutations in the pathogenesis of nephropathy development, APOL1 gene polymorphism in the pathogenesis of nephropathies of various etiologies.

First page

272

Last page

278

For citation: Axmedova N.Sh. – THE SIGNIFICANCE OF GENETIC MUTATIONS IN THE PATHOGENESIS OF THE DEVELOPMENT OF NEPHROPATHY IN CHRONIC KIDNEY DISEASES OF DIFFERENT ETIOLOGIES //New Day in Medicine 2023 11(61): 272-278 https://newdaymedicine.com/index.php/2023/11/27/l-533/

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