46 -11 (61) 2023 — Akhmadiev Edvard Ericovich — EVALUATION OF BIOCHEMICAL AND ULTRASOUND MARKERS FOR PREDICTING THE DEVELOPMENT OF PREECLAMPSIA

EVALUATION OF BIOCHEMICAL AND ULTRASOUND MARKERS FOR PREDICTING THE DEVELOPMENT OF PREECLAMPSIA

Akhmadiev Edvard Ericovich Republican Specialized Scientific and Practical Medical Center of Obstetrics and Gynecology Uzbekistan

Resume

Preeclampsia (PE) occupies one of the most important places among the problems of scientific and practical obstetrics, the frequency of which, according to WHO data, can reach up to 28% among pregnant women, thereby representing the main part of hypertensive conditions during pregnancy. Moreover, severe PE occurs in 1.3 – 6.7% of pregnant women. Preeclampsia is diagnosed after the 20th week of pregnancy. Complications that can be fatal include premature placental abruption, disseminated intravascular coagulation (DIC), cerebral hemorrhage, liver failure, and acute renal failure. This review focuses on biochemical and ultrasound markers of high risk of preeclampsia. Of particular interest is the balance of proangiogenic (PIGF) and antiangiogenic (sFlt) growth factors at different stages of pregnancy; correct interpretation of the sFlt/PIGF ratio and correlation with anamnesis data already allows expanding the criteria for the prevention of preeclampsia and opens up prospects for optimizing obstetric tactics in the third trimester of pregnancy.

Key words: preeclampsia, early diagnosis of preeclampsia, biochemical markers of preeclampsia, ultrasound markers of preeclampsia, sFlt-1/PlGF, placental growth factor (PIGF), pulsatility index of the uterine arteries

First page

279

Last page

283

For citation: Akhmadiev Edvard Ericovich – EVALUATION OF BIOCHEMICAL AND ULTRASOUND MARKERS FOR PREDICTING THE DEVELOPMENT OF PREECLAMPSIA //New Day in Medicine 2023 11(61): 279-283 https://newdaymedicine.com/index.php/2023/11/28/l-534/

LIST OF REFERENCES:

1. Sidorova I.S., Nikitina N.A., Unanyan A.L. Preeclampsia and reduction of maternal mortality in Russia. [Preeklampsiya i snizhenie materinskoj smertnosti v Rossii]. Akusherstvo i ginekologiya. 2018;(1):107–12. (In Russ.). https://doi.org/10.18565/aig.2018.1.107-112.
2. Kurtser M.A., Shamanova M.B., Sinitsina O.V. et al. Clinical rationale for determining the ratio sFlt-1/PlGF for early detection and evaluation of the severity of preeclampsia. [Klinicheskoe obosnovanie opredeleniya sootnosheniya sFlt-1/PlGF s cel’yu rannego vyyavleniya i ocenki stepeni tyazhesti preeklampsii]. Akusherstvo i ginekologiya. 2018;(11):114–20. (In Russ.). https://doi.org/10.18565/aig.2018.11.114-120.
3. Say L., Chou D., Gemmill A. et al. Global causes of maternal death: a WHO systematic analysis. // Lancet Glob Health. 2014;2(6):e323–33. https://doi.org/10.1016/S2214-109X(14)70227-X.
4. Redman C.W., Staff A.C. Preeclampsia, biomarkers, syncytiotrophoblast stress, and placental capacity. // Am J Obstet Gynecol. 2015;213(4 Suppl):S9.e1, S9–11. https://doi.org/10.1016/j.ajog.2015.08.003.
5. Sánchez O., Llurba E., Marsal G. et al. First trimester serum angiogenic/ anti-angiogenic status in twin pregnancies: relationship with assisted reproduction technology. // Hum Reprod. 2012;27(2):358-65. https://doi.org/10.1093/humrep/der394.
6. Zeisler H., Llurba E., Chantraine F. et al. Predictive value of the sFlt-1:PlGF ratio in women with suspected preeclampsia. N Engl J Med.
   2016;374(1):13–22. https://doi.org/10.1056/NEJMoa1414838.
7. Karumanchi S.A., Maynard S.E., Stillman I.E. et al. Preeclampsia: a renal perspective. // Kidney Int. 2005;67(6):2101–13. https://doi.org/10.1111/j.1523-1755.2005.00316.x.
8. Narang K., Szymanski L.M. Multiple gestations and hypertensive disorders of pregnancy: What do we know? // Curr Hypertens Rep. 2020;23(1):1.https://doi.org/10.1007/s11906-020-01107-4.
9. Francisco C., Wright D., Benkő Z. et al. Competing-risks model in screening for pre-eclampsia in twin pregnancy according to maternal
   factors and biomarkers at 11–13 weeks’ gestation. // Ultrasound Obstet Gynecol. 2017;50(5):589–95. https://doi.org/10.1002/uog.17531.
10. Kozłowski S., Stelmaszczyk-Emmel A., Szymusik I. et al. sFlt-1, not PlGF, is related to twin gestation choronicity in the first and third trimesters of
    pregnancy. // Diagnostics (Basel). 2021;11(7):1181. https://doi.org/10.3390/diagnostics11071181.
11. Phipps E.A., Thadhani R., Benzing T., Karumanchi S.A. Pre-eclampsia: pathogenesis, novel diagnostics and therapies. // Nat Rev Nephrol.
    2019;15(5):275–89. https://doi.org/10.1038/s41581-019-0119-6.
12. Erratum in: Nat Rev Nephrol. 2019;15(6):386. https://doi.org/10.1038/s41581-019-0156-1.
13. Fisher S.J. Why is placentation abnormal in preeclampsia? // Am J Obstet Gynecol.2015;213(4Suppl):S115–22. https://doi.org/10.1016/j.ajog.2015.08.042.