47 -11 (61) 2023 — Akhmedova Gulmira Ikhtiyarovna — INFLUENCE OF ERYTHROPOIETIN ON THE CLINICAL COURSE OF CHRONIC HEART FAILURE
INFLUENCE OF ERYTHROPOIETIN ON THE CLINICAL COURSE OF CHRONIC HEART FAILURE
Akhmedova Gulmira Ikhtiyarovna Bukhara State Medical Institute named after Abu Ali ibn Sina
Resume
Anemia was detected in 14 (24.8%) patients, including 12 patients with iron deficiency. By the end of 12 weeks of treatment, there was a significant increase of 36% in the distance walked according to the results of the 6-minute walk test, an improvement in the functional class of CHF according to NYHA, an increase in LVEF by 32.5%, an increase in hemoglobin level by 12.5% (p <0.001), hematocrit by 5.8% (p<0.001), red blood cells by 8% (p<0.001). Correction of anemia in patients with CHF and IHD with iron supplements and erythropoietin against the background of standard therapy leads to a significant improvement in the clinical course of CHF and IHD.
Key words: chronic heart failure, coronary heart disease, anemia, erythropoietin.
First page
284
Last page
288
For citation: Akhmedova Gulmira Ikhtiyarovna – INFLUENCE OF ERYTHROPOIETIN ON THE CLINICAL COURSE OF CHRONIC HEART FAILURE //New Day in Medicine 2023 11(61): 284-288 https://newdaymedicine.com/index.php/2023/11/28/l-535/
LIST OF REFERENCES:
- Silverberg D.S., Wexler D., Sheps D. et al. The effect of correction of mild anemia in severe, resistant congestiv heart failure using subcutaneous erytropoietin and intravenous iron. A randomized controlled study. // J Am Coll Cardiol 2001;37:1775-1780.
- Tereshchenko S.N., Atroshchenko E.S., Uskach T.M. et al. Anemia as complication of chronic heart failure: prevalence, treatment, prognosis. // Ter Arkh 2008;80(9):90-5. Russian (Tereshchenko S. N., Atroschenko E. S., Uskach T. M. et al. Anemia as a complication of chronic heart failure: prevalence, prognosis, and treatment. Therapeutic Archive 2008;9:90-95).
- Chernov V.M. ed. Anemia is a hidden epidemic. M.: MegaPro; 2004. Russian (Chernov V. M., editor. Anemia is a hidden epidemic , Moscow: MegaPro; 2004).
- Arutjunov G.P. Anemia in patients with chronic heart failure. Serdechnaja Nedostatochnost’ 2003;4(5):224-228. Arutyunov (Арутюнов G. P. Anemia у in patients with chronic heart failure. Heart Failure 2003;4(5):224-228).
- Tereshchenko S.N., Dzhainani N.A., Uskach T.M., Kochetov A.G. Anemia and chronic heart failure. Kardiologija 2004;44(7):73-6. Tereshchenko S. N., Dzhainani N. A., Uskach T. M., Kochetov A. G. Anemia and chronic heart failure. Cardiology 2004;44(7):73-6).
- Shilov A.M., Mel’nik M.V., Sarycheva A.A. Anemia in heart failure. Russkij medicinskij zhurnal 2003; 11(9): 545-548. Shilov (Шилов A.M., Melnik M. V., Sarycheva A. A. Anemia in heart failure. // Russian Medical Journal 2003;11(9):545-548).
- Silverberg D.S., Iaina A., Wexler D. et al. The pathological consequences of anaemia. Clin Lab Haematology 2001;23(1):1-6.
- Steinborn W., Doehner W., Anker S.D. Anemia in chronic heart failure – frequency and prognostic impact. // Clin Nephrology 2003;60(Suppl 1):103-107.
- Singh A.K. et al. Correction of anemia with epoetin alfa in chronic kidney disease. // N Engl J Med 2006;355:2085-2098.
- Sarnak MJ, Tighiouart H, Manjunath G, et al. Anemia as a risk factor for cardiovascular disease in the Atherosclerosis Risk in Communities (ARIC) study. // J Am Coll Cardiol 2002;40:27-33.
- Guyatt G.H. Measurement of health-related quality of life in heart failure. // J Am Coll Cardiol 1993;22(4 Suppl A):185A-191A.
- Devereux R., Reichek N. Echocardargraphic assesment of left ventricular mass in man. // Circulation 1977;55:613-618.
- Silverberg D.S., Wexler D., Blum M. et al. The use subcutaneous erytropoietin and intravenous iron for the treatment of the anemia of severe, resistant congestiv heart failure improves cardiac and renal function, functional cardiac class, and makedly reduces hospitalization. // J Am Coll Cardiol 2000;35:1737-1744.
- Wisniackl N., Aimson P., Lyle M. Is anemia a cause of heart failure in the elderly? // Heart 2001; 85 suppl I:4.