51 -11 (61) 2023 — Raimkulov R.S. — PATHOMORPHOLOGY AND PATOMORPHOSIS OF MESENTERIAL LYMPH NODES IN CORONAVIRUS INFECTION
PATHOMORPHOLOGY AND PATOMORPHOSIS OF MESENTERIAL LYMPH NODES IN CORONAVIRUS INFECTION
Raimkulov R.S. Tashkent Medical Academy
Resume
Information about specific changes in immune system organs is very limited. A wide range of changes was revealed – from the devastation of B-dependent and T-dependent zones of lymphoid tissue, to hyperplasia of tissue of the lymph nodes and spleen of varying degrees. There is no doubt about the relevance of further identification of apoptosis of cells of the immune system as one of the causes of lymphopenia and immune dysfunction in COVID-19, which has prospects for finding means of pharmacological influence on the process of lymphocytic apoptosis.
Key words: coronavirus infection, COVID-19, pathomorphology, lymphopenia, lymph nodes.
First page
305
Last page
310
For citation: Raimkulov R.S. – PATHOMORPHOLOGY AND PATOMORPHOSIS OF MESENTERIAL LYMPH NODES IN CORONAVIRUS INFECTION //New Day in Medicine 2023 11(61): 305-310 https://newdaymedicine.com/index.php/2023/11/29/l-539/
LIST OF REFERENCES:
- Мокрышева Н.Г., Галстян Г.Р., Киржаков М.А., и др. Пандемия COVID-19 и эндокринопатии // Проблемы эндокринологии. 2020;66(1). [Mokrysheva NG, Galstyan GR, Kirzhakov MA, et al. Pandemiya COVID-19 i endokrinopatii. Problemy endokrinologii. 2020;66(1). (In Russ).
- Сборник методических рекомендаций, алгоритмов действий медицинских работников на различных этапах оказания помощи, чек-листов и типовых документов, разработанных на период наличия и угрозы дальнейшего распространения новой коронавирусной инфекции в Санкт-Петербурге. Версия 1,0 от 17.04. 2020. – СПб.; 2020;157.
- Vrachimis A, Iacovou I, Giannoula E, Giovanella L. Endocrinology in the time of COVID-19: management of thyroid nodules and cancer. // Eur J Endocrinol. 2020;183(1):G41-G48. https://doi.org/10.1530/EJE-20-0269.
- Pal R., Banerjee M. COVID 19 and the endocrine system: exploring the unexplored. J Endocrinol Invest. 2020;43(7):1027-1031. https://doi.org/10.1007/s40618-020-01276-8.
- Perez-Moreiras J.V., Gomez-Reino J.J., Maneiro J.R. et al. Efficacy of Tocilizumab in patients with moderate-to-severe corticosteroid-resistant graves orbitopathy: a randomized clinical trial. // Am J Ophthalmol. 2018;195:181-190. https://doi.org/10.1016/j.ajo.2018.07.038.
- Desailloud R., Hober D. Viruses and thyroiditis: an update. // Virol J. 2009;6:5. https://doi.org/10.1186/1743-422X-6-5.
- De Jongh F.E., Jobsis A.C., Elte J.W. Thyroid morphology in lethal non-thyroidal illness: a post-mortem study. // Eur J Endocrinol. 2001;144(3):221-226. https://doi.org/10.1530/eje.0.1440221.
- Wei L., Sun S., Xu C. et al. Pathology of the thyroid in severe acute respiratory syndrome. // Hum Pathol. 2007;38(1):95-102.
- Fliers E., Bianco A.C., Langouche L., Boelen A. Thyroid function in critically ill patients. // Lancet Diabetes Endocrinol. 2015;3(10):816-825. https://doi.org/10.1016/S2213-8587(15)00225-9.
- Brancatella A., Ricci D., Viola N. et al. Subacute thyroiditis after SARS-CoV-2 infection. // J Clin Endocrinol Metab. 2020;105(7): dgaa276. https://doi.org/10.1210/clinem/dgaa276.
- Dong Y.H., Fu D.G. Autoimmune thyroid disease: mechanism, genetics and current knowledge. // Eur Rev Med Pharmacol Sc. 2014;18(23):3611-3618.