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  • 49 -2 (34) 2021 — Ismailov O’.S., Batirov D.Yu., — ROLE OF rs1042714 POLYMORPHISM IN THE ADRB2 GENE IN THE PATHOGENESIS OF NOSOLOGICAL SYNTROPY OF GALLSTONE DISEASE AND METABOLIC SYNDROME

49 -2 (34) 2021 — Ismailov O’.S., Batirov D.Yu., — ROLE OF rs1042714 POLYMORPHISM IN THE ADRB2 GENE IN THE PATHOGENESIS OF NOSOLOGICAL SYNTROPY OF GALLSTONE DISEASE AND METABOLIC SYNDROME

ROLE OF rs1042714 POLYMORPHISM IN THE ADRB2 GENE IN THE PATHOGENESIS OF NOSOLOGICAL SYNTROPY OF GALLSTONE DISEASE AND METABOLIC SYNDROME

Ismailov Uktam.Safayevich., Ministry of Health of the Republic of Uzbekistan. Main Directorate of Science and Education. Urgench branch of the Tashkent Medical Academy.

Batirov D.Yu., Ministry of Health of the Republic of Uzbekistan. Main Directorate of Science and Education. Urgench branch of the Tashkent Medical Academy.

Boboev Q.T., Ministry of Health of the Republic of Uzbekistan. Main Directorate of Science and Education. Urgench branch of the Tashkent Medical Academy.

Rakhimov A.P. Ministry of Health of the Republic of Uzbekistan. Main Directorate of Science and Education. Urgench branch of the Tashkent Medical Academy.

Resume

Objective: to study the role of the rs1042714 polymorphism in the ADRB2 gene in the pathogenesis of gallstone disease in combination with MS. Material and methods: Molecular genetic studies were carried out in the Department of Molecular Medicine and Cell Technologies of the RSNPMC Hematology. The analysis of the associations of the rs1042714 polymorphisms of the ADRB2 gene was carried out using a case-control model. The main group consisted of 118 patients with cholelithiasis in combination with MS living in the Khorezm region. Results: As a result of our research, we revealed a significant association of the homozygous genotype for the Glu allele with the development of gallstone disease in combination with MS. The indicator of the ratio of the chances of developing gallstone disease in combination with MS in carriers of this genotype was OR = 3.0 at 95% CI: 1.124-7.905. The relative risk of disease was RR = 2.7 at 95% CI: 1.099-6.691. Conclusion: Our results allow us to conclude that the homozygous Glu / Glu genotype plays an important role in the formation of gallstone disease and obesity in people of Uzbek nationality.

Key words: Gallstone disease, metabolic syndrome, ADRB2, Glu / Glu, polymorphism, gene, allele, genotype, pathogenesis, obesity

First page

249

Last page

253

For citation: Ismailov O’.S., Batirov D.Yu., Boboev Q.T., Rakhimov A.P. Role of rs1042714 polymorphism in the adrb2 gene in the pathogenesis of nosological syntropy of gallstone disease and metabolic syndrome //New Day in Medicine 2(34)2021 249-253 https://cutt.ly/xncKnJ0

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