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  • 43 -12 (62) 2023 — Narzullaev N.U., Shodmonov Zh.B. — CHARACTERISTICOF THE IMMUNE STATUS OF PATIENTS IN THE ACUTE PERIOD OF ISCHEMIC STROKE

43 -12 (62) 2023 — Narzullaev N.U., Shodmonov Zh.B. — CHARACTERISTICOF THE IMMUNE STATUS OF PATIENTS IN THE ACUTE PERIOD OF ISCHEMIC STROKE

CHARACTERISTICOF THE IMMUNE STATUS OF PATIENTS IN THE ACUTE PERIOD OF ISCHEMIC STROKE

Narzullaev N.U., Bukhara State Medical Institute named after Abu Ali ibn Sina

Shodmonov Zh.B. Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

To study the immune status of patients in an acute period of ischemic stroke, a clinical and immunological observation of 45 patients was performed. At the 2nd day after the onset of the disease, an increase in the leukocyte count (p˂0.01) and a decrease in lymphocytes (p˂0.05), T-lymphocytes (CD3+) (p<0.01), T-helpers (CD4+) (p˂0.01) and cytotoxic T-lymphocytes (CD8+) (p˂0.05) were observed. There was also a tendency to decrease the content of natural killers (NK cells, CD16+) and cells that express the receptors for IL-2 (CD25+) (p˃0.05). In the humoral immunity, an in–crease in the number of B-lymphocytes (CD20+) (p˂0.05) and dysgammaglobulinaemia due to the ten- dency to hyperfunction IgA and IgM (p˃0.05) and an increase in IgG (p˂0.05) was observed. Deviation of the immune status of normal values was more pronounced with increasing severity of neurological symptoms and infarct size. With a moderate and severe stroke on the NIHSS scale and the infarct size of more than 15 mm, more pronounced lymphopenia (p˂0.05) was noted with a significant decrease in the T-lymphocyte (CD3+) (p˂0.05), T-lymphocyte subpopulations (CD4+; p˂0.05) and CD8+; p<0.005), as well as NK cells (CD16+) and cells expressing receptors for IL-2 (CD25+) (p˃0.05). Thus, these studies demonstrate the involvement of the immune system in a complex set of reactions involved in the development of cerebral accidents and suggest an increased susceptibility of these patients to the de- velopment of infectious complications. The lack of immune status changes against standard therapy requires an immune-corrective therapy (in case of violations of basic parameters of the immune system).

Key words: ischemic stroke, immune system, immune status, cellular and humoral immunity.

First page

245

Last page

252

For citation: Narzullaev N.U., Shodmonov Zh.B. – CHARACTERISTICOF THE IMMUNE STATUS OF PATIENTS IN THE ACUTE PERIOD OF ISCHEMIC STROKE //New Day in Medicine 2023 12(62): 245-252 https://newdaymedicine.com/index.php/2023/12/16/l-597/

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