49 -12 (62) 2023 — Khaldarbekova M.A., Ashurova D.T. — PATHOGENETIC FEATURES OF THE CLINICAL COURSE OF ANEMIA IN JUVENILE RHEUMATOID ARTHRITIS

PATHOGENETIC FEATURES OF THE CLINICAL COURSE OF ANEMIA IN JUVENILE RHEUMATOID ARTHRITIS

Khaldarbekova M.A., Tashkent Pediatric Medical Institute

Ashurova D.T. Tashkent Pediatric Medical Institute

Resume

Anemia initiated by juvenile rheumatoid arthritis (JRA) has its own specific pathogenesis, which was revealed in detail in the present study. When studying erythropoietin-stimulating hormone in JRA children with mild anemia, it was 20.3±3.1 mIU/ml, and in patients with moderate anemia it was 12.1±1.3 mIU/ml (p <0.001). There is an inverse relationship between the activity of the process of juvenile rheumatoid arthritis, caused by activation of the cytokine system, in particular interleukin 6 and erythropoietin stimulating factor of blood serum (p <0.001). Ferritin as an acute phase indicator increased in patients in groups 1 and 2 to 104.6±39.4 and 212.7±14.8 ng/ml, however, it did not in any way reflect the state of iron depot in the body p<0.001 in all comparison groups and between themselves. Ferroportin in patients with mild anemia was 0.21±0.04 ng/ml, which indicates its decrease. Based on this, we can conclude that the more ferritin increases, ferroportin decreases in direct proportion to it.

Key words: JRA, anemia, ferritin, erythropoietin, ferroportin.

First page

284

Last page

289

For citation: Khaldarbekova M.A., Ashurova D.T. – PATHOGENETIC FEATURES OF THE CLINICAL COURSE OF ANEMIA IN JUVENILE RHEUMATOID ARTHRITIS //New Day in Medicine 2023 12(62): 284-289 https://newdaymedicine.com/index.php/2023/12/19/l-634/

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