54 -12 (62) 2023 — Murotov Kh.A. — PATHOMORPHOLOGY OF PULMONARY BLOOD VESSELS IN COVID-19

PATHOMORPHOLOGY OF PULMONARY BLOOD VESSELS IN COVID-19

Murotov Kh.A.  Center for the Development of Professional Qualifications of Medical Workers under the Ministry of Health of the Republic of Uzbekistan

Resume

In this article, the morphological changes in the walls of pulmonary blood vessels caused by the infection of COVID-19 are studied. During the pandemic of 2021, fragments of the lungs of people who died from this disease were taken from the areas rich in blood vessels and studied histologically. It is known that the abundance of ACE2 enzyme in the endothelium of pulmonary blood vessels, their extensive damage by SARS-CoV-2, the development of a strong and scattered discirculation process, which continues with the appearance of endotheliosis, endothelitis, coagulopathy, vasculitis, microvasculitis thrombi, leads to the development of diffuse hemorrhagic inflammation in the lung tissue. Initially, all the blood vessels of the lung tissue are suddenly filled, the diapedesis continues with the development of hemorrhages and hemorrhagic edema in the alveoli. The development of fibrinoid swelling and fibrinoid necrosis endotheliitis in the walls of the pulmonary blood vessels, the appearance of thrombus in both large and small vessels, manifested by the development of macro- and microangiopathy. it is observed that During the proliferative period of COVID-19, lympho-histiocytic infiltration, and finally sclerosing, are detected in and around the walls of blood vessels, then in the walls of alveoli.                                             

Keywords: COVID-19, lungs, blood vessels, fibrinoid necrosis, thrombosis, microangiopathy, hemorrhage.

First page

308

Last page

313

For citation: Murotov Kh.A. – PATHOMORPHOLOGY OF PULMONARY BLOOD VESSELS IN COVID-19 //New Day in Medicine 2023 12(62): 308-313 https://newdaymedicine.com/index.php/2023/12/20/l-639/

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