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  • 65 -12 (62) 2023 — R.K.Dadabaeva — THE SIGNIFICANCE OF CLINICAL-METABOLIC AND HORMONAL CHANGES IN OBESITY PHENOTYPES IN RENAL DYSFUNCTION

65 -12 (62) 2023 — R.K.Dadabaeva — THE SIGNIFICANCE OF CLINICAL-METABOLIC AND HORMONAL CHANGES IN OBESITY PHENOTYPES IN RENAL DYSFUNCTION

THE SIGNIFICANCE OF CLINICAL-METABOLIC AND HORMONAL CHANGES IN OBESITY PHENOTYPES IN RENAL DYSFUNCTION

R.K. Dadabaeva  Tashkent Medical Academy

Resume

The purpose of the study is to assess the role of leptin (LEP) gene G2548A polymorphism in the course of phenotypes of obesity, and the occurrence of clinical-metabolic, immune-inflammatory and hormonal changes in it, as well as the development of kidney dysfunction.

Research material and methods. The study involved 224 women of reproductive age of Uzbek ethnicity who were diagnosed with obesity. The observed women were classified into 2 groups according to the criteria for metabolic syndrome, Group 1 consisting of 133 women with an average age of 42.0±0.5 with Metabolically Complicated Obesity (MCO); Group 2 consisting of 91 women with an average age of 41.7±0.7 with a Metabolically Healthy Obesity (MHO). The control group consisted of 45 healthy volunteers (females, average age 43.2±0.8, BMI<30 kg/m2, waist circumference less than 80 cm). In groups, the indicators of total and biochemical blood taxilies, lipid spectrum, and uric acid content, serum leptin, cystatin S, uromodulin and microalbuminuria in the forehead in the immunosorbent method were evaluated in a comparative way. Also, the polymerase chain reaction method found the extent to which the LEP gene G2548A polymorphism occurs in groups.

Conclusion. The G allele and GG genotype of the polymorphism of the LEP gene G2548A have an aggressive property in the development of renal dysfunction, leading to the development of clinical-metabolic and hormonal disorders in women of fertile age of the Uzbek nationality, in which metabolically complicated obesity is detected. The A allele and AA genotype of this gene have a protective effect in these pathological conditions.

Key words. Obesity phenotypes, gene polymorphisms, leptin, cystatin S, creatinine, microalbuminuria.

First page

372

Last page

381

For citation: R.K.Dadabaeva – THE SIGNIFICANCE OF CLINICAL-METABOLIC AND HORMONAL CHANGES IN OBESITY PHENOTYPES IN RENAL DYSFUNCTION //New Day in Medicine 2023 12(62): 372-381 https://newdaymedicine.com/index.php/2023/12/26/l-666/

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