10 -1 (63) 2024 — Mamathujaeva G.N., Ikrаmov A.F. — CHANGES IN THE IMMUNOLOGICAL PARAMETERS OF LACRIMAL FLUID IN MILD MYOPIA IN CHILDREN AND ADOLESCENTS WITH TUBERCULOSIS

CHANGES IN THE IMMUNOLOGICAL PARAMETERS OF LACRIMAL FLUID IN MILD MYOPIA IN CHILDREN AND ADOLESCENTS WITH TUBERCULOSIS

Mamathujaeva G.N., Andijan State Medical Institute

Ikrаmov A.F., Andijan State Medical Institute

Aleynik V.A. Andijan State Medical Institute

Resume

The authors consider changes in the immunological parameters of tear fluid in mild myopia in children and adolescents with tuberculosis. As a result of the studies, a significant relationship was established between tuberculosis and low myopia. A pronounced pro-inflammatory reaction was detected in the tear fluid of children and adolescents with myopia and patients with tuberculosis. This was manifested in an increase in the level of pro-inflammatory interleukin TNF-α and a decrease in the level of anti-inflammatory interleukin IL-10 and TGF-β1, while a decrease in the content of protease inhibitors α-1-antitrypsin and α-2-macroglobulin in the tear fluid. This reaction may indicate the presence of an inflammatory process in the eyes of these children. A more pronounced pro-inflammatory reaction was observed in all groups in girls, while in boys it was less pronounced. At the same time, there was no pronounced relationship between age and the manifestation of myopia in children with tuberculosis. This may indicate the influence of gender factors on the development of myopia in children with tuberculosis.

 Key words: children and adolescents, mild myopia, tuberculosis, anti-inflammatory interleukins, protease inhibitors.

First page

50

Last page

56

For citation: Mamathujaeva G.N., Ikrаmov A.F., Aleynik V.A. – CHANGES IN THE IMMUNOLOGICAL PARAMETERS OF LACRIMAL FLUID IN MILD MYOPIA IN CHILDREN AND ADOLESCENTS WITH TUBERCULOSIS //New Day in Medicine 2024 1(63): 50-56 https://newdaymedicine.com/index.php/2024/01/05/l-737/

LIST OF REFERENCES:

1. Аветисов С. Э., Кащенко Т. П., Шамшинова А. М. Зрительные функции и их коррекция у детей / М.: Медицина. 2005; 20(1):5.
2. Сахарова С.В., Рухлова С.А., Петров С.А.Осложненная миопия высокой степени при различных состояниях иммунной системы. Съезд офтальмологов России, 9-й (16-18 июня 2010 г.): Тез. докл.- М.: Издательство «Офтальмология», 2010; 524.
3. Шейко В. И., Пантелеев П. Г. Состояние иммунной системы в условиях миопии до-3 диоптрий // Молодий вчений. 2015; 9(2):102-104.
4. Guo, D., Qi, J., Du, Y., Zhao, C., Liu, S., Lu, Y., Zhu, X. Tear inflammatory cytokines as potential biomarkers for myopic macular degeneration // Experimental Eye Research. 2023; 235:109648-109648.
5. Yu, Q., Wang, C., Liu, Z., Yue, Y., Hsiao, Y., Zhou, Q., & Zhou, J. Association between inflammatory cytokines and oxidative stress levels in aqueous humor with axial length in human myopia // Experimental eye Research. 2023; 109670-109670.
6. Yuan, J., Wu, S., Wang, Y., Pan, S., Wang, P., & Cheng, L. Inflammatory cytokines in highly myopic eyes // Scientific Reports. 2019; 9(1):3517-351.
7. Zhu, X., Zhang, K., He, W., Yang, J., Sun, X., Jiang, C., Lu, Y. Proinflammatory status in the aqueous humor of high myopic cataract eyes // Experimental eye research. 2016; 142:13-18.