11 -1 (63) 2024 — V.B. Salomov, U.V.Bafoyev — MONITORING OF COORDINATION AND AMNESTIC DISORDERS OF EXPERIMENTAL TRAUMATIC BRAIN INJURY

MONITORING OF COORDINATION AND AMNESTIC DISORDERS OF EXPERIMENTAL TRAUMATIC BRAIN INJURY

V.B. Salomov, Bukhara branch of the Republican Scientific Center for Emergency Medical Care Uzbekistan

U.V.Bafoyev Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Relevance. It is indicated that the low effectiveness of treatment and high disability after TBI require new treatment methods and testing of new drugs not only in the clinic and in experiments. Neuropsychiatric tests were used to assess neurological disturbances after experimental traumatic brain injury in experimental animals.

Purpose of the study: Coordination and amnestic disturbances were studied in white rats after modeling an experimental mild traumatic brain injury.

Materials and methods of research. The work was carried out on 60 white rats of both sexes, weighing about 130-150 grams, of sexually mature age. The animals were trained to walk on a block and find a hidden platform underwater (Morris maze) prior to the study. They have formed protective somatic reflexes. Mild traumatic brain injury was produced in animals under inhalation anesthesia. Their coordination disturbances using the “walking on a raised beam” method and amnestic disturbances using the “Morris water maze” before and after experimental mild traumatic brain injury were studied in a comparative manner.

Results of the study: After modeling an experimental mild traumatic brain injury, motor and amnestic disturbances were induced in experimental animals, which were assessed by neuropsychiatric tests.

Conclusions: Our proposed psychoneurological tests specifically and easily assessed coordination
disturbances using the “walking on a raised beam” method and amnestic disturbances in the “Morris water maze”

Key words: Experimental traumatic brain injury, psychoneurological tests, coordination and amnestic disturbances.

First page

57

Last page

63

For citation: V.B. Salomov, U.V.Bafoyev – MONITORING OF COORDINATION AND AMNESTIC DISORDERS OF EXPERIMENTAL TRAUMATIC BRAIN INJURY //New Day in Medicine 2024 1(63): 57-63 https://newdaymedicine.com/index.php/2024/01/05/l-738/

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