22 -1 (63) 2024 — Ishankulova Sh.A., Khasanova D.A. — NORMATIVE MORPHOLOGICAL SPECIFICITY OF THE SKININ WHITE OUTBRED RATS

NORMATIVE MORPHOLOGICAL SPECIFICITY OF THE SKININ WHITE OUTBRED RATS

Ishankulova Sh.A., Bukhara State Medical Institute named after Abu Ali ibn Sina

Khasanova D.A., Bukhara State Medical Institute named after Abu Ali ibn Sina

Latipov I.I. Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Features of the formation of skin as an organ are basic knowledge for studying the process of aging and regeneration. Also, when studying this issue, it is necessary to take into account exogenous factors affecting the skin, which, in turn, is a “barrier organ”. The study was carried out on the skin of white outbred male rats in the late prenatal and early postnatal periods. At the initial stages of its formation, the skin undergoes its morphofunctional changes in the form of thickening of the epidermis and the appearance of the stratum corneum, as well as thickening of the dermis and changes in the shape of the collagen fibers included in its structure. The formation of skin as a full-fledged “barrier organ” occurs in early postnatal ontogenesis.

Key words: skin, ontogeny of rat skin, epidermis, dermis, layers of the skin.

First page

114

Last page

119

For citation: Ishankulova Sh.A., Khasanova D.A.,Latipov I.I. – NORMATIVE MORPHOLOGICAL SPECIFICITY OF THE SKININ WHITE OUTBRED RATS //New Day in Medicine 2024 1(63): 114-119 https://newdaymedicine.com/index.php/2024/01/12/l-750/

LIST OF REFERENCES:

  1. Klinova N.G., Ivanova I.N., Popov V.V., Rusinov V.I Akupunktura v lechenii bol’nyh hronicheskimi dermatozami [Acupuncture in the treatment of patients with chronic dermatoses]. // Vestnik Volgogradskogo gosudarstvennogo medicinskogo universiteta [Journal of Volgograd StateMedical University], 2020; 2(74):127-129. (In Russ., abstr. in Engl.).
  2. Mishina E.S., Zatolokina M.A., Sergeeva S.Ju. Izuchenie faktorov dinamicheskogo strukturirovanija kollagenovyh volokon v jeksperimente [Experimental study of the factors of dynamic structuring of collagen fibers]. // Morgologia [Morphology], 2019; 11(2):99. (In Russ., abstr. in Engl.).
  3. Omel’yanenko N.P., Slutskii L.I. Soedinitel’naya tkan’ (gistofiziologiya i biokhimiya). Vol. 1 [Connective tissue (histophysiology and biochemistry)]. S.P. Mironov (ed.). Moscow: Izvestiya, 2009; 1:308. (In Russ., abstr. in Engl.).
  4. Fetisov S.O., Alekseeva N.T., Nikitjuk D.B., et al. Modelirovanie kak metod ocenki specificheskih morfo-funkcional’nyh patternov pri regeneracii [Modeling as a Method of Specific Morphological and FunctionalPatterns in Regeneration]. // Zhurnal anatomii I gistopatologii [Journal of Anatomy and Histopathology], 2015; 4(4):49-55. (In Russ., abstr. in Engl.).
  5. Fokina E.N., Zagrebin V.L., Fedorova O.V., Tkhabit Khuda Salekh A. Morfologicheskie aspekty razvitiya kozhi na raznyh stadiyah prenatal’nogo onto- geneza [Morphological aspects of skin development at different stages of prenatal ontogenesis]. Aktual’nye problemy eksperimental’noj i klinicheskoj mediciny. Materialy 63-j itogovoj nauchnoj konferencii studentov i molodyh uchenyh [Actual problems of experimental and clinical medicine. Materials of the 63rd final scientific conference of students abstr. in Engl.).
  6. Fibrosis: Methods and Protocols. // Edited by Laure Rittie. 2017; 530 p.
  7. Ghazanfari S., Khademhosseini A., Smit T. H. Mechanisms of lamellar collagen formation in connective tissues. // Biomaterials, 2016; 9(7):74-84.
  8. Sidgwick G. P., McGeorge D., Bayat A. A com- prehensive evidence-based review on the role of topicals and dressings in the management of skin scarring. // Arch Dermatol Res, 2015; 307(6):461-477.

file

download