66 -2 (34) 2021 — Abdullaeva U.K., Ismatova M.N., — MODERN PRESENTATION OF IMMUNOPATHOGENESIS OF CHRONIC GASTRITIS AND ITS SIGNIFICANCE IN CARCINOGENESIS

MODERN PRESENTATION OF IMMUNOPATHOGENESIS OF CHRONIC GASTRITIS AND ITS SIGNIFICANCE IN CARCINOGENESIS

Abdullaeva U.K., Bukhara State Medical Institute, Bukhara, Uzbekistan

Ismatova M.N., Bukhara State Medical Institute, Bukhara, Uzbekistan

Sulaimonova G.T., Bukhara State Medical Institute, Bukhara, Uzbekistan

Amonov M.K., Bukhara State Medical Institute, Bukhara, Uzbekistan

Ergashev B.B. Bukhara State Medical Institute, Bukhara, Uzbekistan

Resume

In the review risk factors which transformations chronic atrophic a gastritis in a stomach cancer promote are analyzed. The characteristic of precancer conditions as increase in risk of development of a cancer of a stomach is given. Processes of a chronic inflammation, an atrophy, intestinal metaplasia, displasia and risk of formation adenocarcinoma of stomach are estimated. The role of a genetic susceptibility of an organism to infected Н pylori, the factors of its pathogenicity promoting metaplasia epithelium is analyzed. It is proved that the combination virulence a microorganism and a genetic susceptibility of the owner conducts to heavier chronic inflammation and faster progressing of a cancer of a stomach, at least, for intestinal type the role of genetic polymorphism interleukins in pathogenesis gastric carcinogenesis is revealed. Also role Toll-like of receptors 4 types (TLR4), participating in recognition Н. pylori is established. Development of the superfluous immune answer of the owner is connected with receptors of this type, leading to damage of a mucous membrane at Н. pylori-infected persons. In particular, carriers TLR4+896А>G polymorphism have heavier atrophy of a stomach and inflammation degree, and also the raised risk a stomach cancer

Key words: chronic gastritis, stomach mucous membrane, stomach cancer, intestinal metaplasia, an atrophy, Helicobacter pylori, gastrin, pepsinogen, interleukin.

First page

337

Last page

343

For citation: Abdullaeva U.K., Ismatova M.N., Sulaimonova G.T., Amonov M.K.,  Ergashev B.B. Modern presentation of immunopathogenesis of chronic gastritis and its significance in carcinogenesis //New Day in Medicine 2(34)2021 337-343 https://cutt.ly/znOYFnM

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