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  • 20 -4 (28/1) 2019 — Khamzaev K., Sharipov A. — EFFICACY OF TREATMENT OF STEROID-RESISTANT NEPHROTIC SYNDROME IN CHILDREN WITH TACROLIMUS

20 -4 (28/1) 2019 — Khamzaev K., Sharipov A. — EFFICACY OF TREATMENT OF STEROID-RESISTANT NEPHROTIC SYNDROME IN CHILDREN WITH TACROLIMUS

EFFICACY OF TREATMENT OF STEROID-RESISTANT NEPHROTIC SYNDROME IN CHILDREN WITH TACROLIMUS

Khamzaev K., Tashkent Pediatric Medical Institute.

Sharipov A. Tashkent Pediatric Medical Institute.

Resume,

The analysis of 16 children who received tacrolimus in the treatment of steroid-resistant nephrotic syndrome was performed. The main indications for treatment with tacrolimus were steroid resistance and steroid dependence (n=15) and serious side effects from other therapies (n=1). The average follow – up period was 6.5 months (range 2.5-18 months). 13 patients (81%) entered complete remission after an average of 2 months (range 0.5-5.5 months) of tacrolimus administration, with 3 patients relapsing during treatment. 3 patients did not respond to treatment with tacrolimus: of these, 2 had partial remissions (13%) and 1 did not respond. Side effects included anemia (n=1), seizures (n=1), worsening of hypertension (n=5), and sepsis (n=1). By the end of the study, all patients remained on tacrolimus. Tacrolimus is an effective, well-tolerated drug for the treatment of resistant forms of nephrotic syndrome in children, with total remission of 81% and partial remission of 13% (total 94%).

Keywords. Steroid-resistant nephrotic syndrome, tacrolimus, proteinuria, prednisone.

First page

87

Last page

91

For citation: Khamzaev K., Sharipov A. Efficacy of treatment of steroid-resistant nephrotic syndrome in children with tacrolimus//New Day in Medicine 4(28)2019 87-91 https://cutt.ly/lby15Ki

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