47 -4 (28/1) 2019 — Madjidova E.N., Xodjieva D.T., — CLINICAL AND NEUROPHYSIOLOGICAL CHARACTERISTICS OF POST-INSULAR COGNITIVE DISORDERS AND ISSUES OF THERAPY OPTIMIZATION
CLINICAL AND NEUROPHYSIOLOGICAL CHARACTERISTICS OF POST-INSULAR COGNITIVE DISORDERS AND ISSUES OF THERAPY OPTIMIZATION
Madjidova E.N., Tashkent Pediatric Medical Institute, Bukhara State Medical Institute.
Xodjieva D.T., Tashkent Pediatric Medical Institute, Bukhara State Medical Institute.
Xaydarova D.K. Tashkent Pediatric Medical Institute, Bukhara State Medical Institute.
Resume,
This article proposes the treatment of an acute period of ischemic stroke with Cellex, which improves speech, praxis and gnosis, which is confirmed by the results of neurophysiological studies. Thus, with mild dementia, disturbances in predominantly attention and regulatory functions were associated with clear impairments of memory, orientation, and visual-spatial function. Neuroimaging in most patients, along with focal post-stroke changes, revealed brain tissue atrophy, changes in white matter, and small focal lesions of the gray matter. It was established that a necessary condition for the verification of the syndrome of post-stroke cognitive impairment. (CI), in addition to the volume and localization of the lesion, should be signs of impaired integrative mental activity of the brain, especially disruption of regulatory functions.
Key words: ischemic stroke; predictors; Cellex; Magnetic resonance imaging
First page
180
Last page
183
For citation: Madjidova E.N., Xodjieva D.T., Xaydarova D.K. Clinical and neurophysiological characteristics of post-insular cognitive disorders and issues of therapy optimization//New Day in Medicine 180-183 https://cutt.ly/Qba6jDx
List of References
- Gutirrez Prez C, Savborg M, Pahlman U, Phlman U, Cederfeldt M, Knopp E, Nordlund A, Astrand R, Wallin A, Fr?jd K, Wijk H, Tarkowski E. High frequency of cognitive dysfunction before stroke among older people. Int J GeriatrPsychiatry. 2011; 26: 622-629. doi: 10.1002/gps.2573.
- Looi JCL, Sachdev P. Differentiation of vascular dementia from AD on neuropsychological tests. Neurology.1999; 53: 670-678. doi: 10.1212/wnl.53.4.670.
- Sachdev PS, Chen X, Brodaty H, Thompson C, Altendorf A, Wen W. The determinants and longitudinal course of post-stroke mild cognitive impairment. J IntNeuropsycholSoc. 2009; 15: 915923. doi: 10.1017/S1355617709990579.
- Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, Launer LJ, Laurent S, Lopez OL, Nyenhuis D, Petersen RC, Schneider JA, Tzourio C, Arnett DK, Bennett DA, Chui HC, Higashida RT, Lindquist R, Nilsson PM, Roman GC, Sellke FW, Seshadri S. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American heart association/American stroke association. Stroke.2011; 42(9): 2672-2713. doi: 10.1161/STR.0b013e3182299496.
- Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med. 2004; 256(3): 183-194. doi: 10.1111/j.1365- 2796.2004.01388.x.
- Cho SJ, Yu KH, Oh MS, Jung S, Lee JH, Koh IS, Bae HJ, Kang Y, Lee BC. Post-stroke memory impairment among patients with vascular mild cognitive impairment. BMC Neurol. 2014; 20: 14: 244. doi: 10.1186/s12883-014-0244-6.
- Snaphaan L, de Leeuw F-E. Poststroke memory function in nondemented patients: a systematic review on frequency and neuroimaging correlates. Stroke. 2007; 38: 198-203. doi: 10.1161/ 01.str.0000251842.34322.8f.
- Liu W, Wong A, Au L, Yang J, Wang Z, Leung EY, Chen S, Ho CL, Mok VC. Influence of amyloid-? on cognitive decline after stroke/transient ischemic attack: Three-Year Longitudinal Study. Stroke. 2015; 46(11): 3074-3080. doi: 10.1161/STROKEAHA.115.010449.
- Jang YK, Kwon H, Kim YJ, Jung NY, Lee JS, Lee J, Chin J, Im K, Jeon S, Lee JM, Seong JK, Kim JH, Kim S, Choe YS, Lee KH, Kim ST, Kim JS, Lee JH, Na DL, Seo SW, Kim HJ. Early- vs late-onset subcortical vascular cognitive impairment. Neurology. 2016; doi: 10.1212/WNL.0000000000002357.
- Jack CR Jr, Therneau TM, Wiste HJ, Weigand SD, Knopman DS, Lowe VJ, Mielke MM, Vemuri P, Roberts RO, Machulda MM, Senjem ML, Gunter JL, Rocca WA, Petersen RC. Transition rates between amyloid and neurodegeneration biomarker states and to dementia: a population-based, longitudinal cohort study. Lancet Neurol. 2016; 15(1): 56-64. doi: 10.1016/S1474- 4422(15)00323-3.