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  • 99 -2 (34) 2021 — Sobirov U.Yu., Rixsiev U.Sh., — PROTEIN METABOLISM IN CHILDREN, SUFFERING FROM VITILIGO, DEPENDING ON MICROBIOCYNOSIS OF INTESTINE AND METHODS OF THIS CORRECTION

99 -2 (34) 2021 — Sobirov U.Yu., Rixsiev U.Sh., — PROTEIN METABOLISM IN CHILDREN, SUFFERING FROM VITILIGO, DEPENDING ON MICROBIOCYNOSIS OF INTESTINE AND METHODS OF THIS CORRECTION

PROTEIN METABOLISM IN CHILDREN, SUFFERING FROM VITILIGO, DEPENDING ON MICROBIOCYNOSIS OF INTESTINE AND METHODS OF THIS CORRECTION

Sobirov U.Yu., Republican Specialized Scientific and Practical Medical Center for Dermatovenereology and Cosmetology of the Ministry of Health of the Republic of Uzbekistan

Rixsiev U.Sh., Tashkent Pediatric Medical Institute

Mamadiev A.A., Republican Specialized Scientific and Practical Medical Center for Dermatovenereology and Cosmetology of the Ministry of Health of the Republic of Uzbekistan Jizzak Regional Regional Branch of the Republican Specialized Scientific and Practical Medical Center of Dermatovenereology and Cosmetology of the Ministry of Health of the Republic of Uzbekistan,

Yuldashev M.A. Jizzak Regional Regional Branch of the Republican Specialized Scientific and Practical Medical Center of Dermatovenereology and Cosmetology of the Ministry of Health of the Republic of Uzbekistan, Tashkent Pediatric Medical Institute

Resume

Subjects of the inquiry: blood, faeces, salvia of 132 children suffered from vitiligo at the age from 1 to 16 years.

Aim of the inquiry. To study protein metabolism, microbiocynosis of intestine and disintoxicational function of liver in children suffered from vitiligo, depending on clinical forms of disease and to improve present methods of therapy.

Methods of inquiry: clinical, bacteriological, biochemical.

The results ahieved and their novelty. For the first time in children with vitiligo aminoacid blood spectrum, depending on clinical forms of disease, was researched. At the same time with hyper-aminoacidemia changes of correlation between different aminoacids were revealed: reduce of phenylalanine/tyrosine, histidine/glutamine acid and serine/glycine. Coefficients raise of asparagin acid/alanin, glutamine acid/prolin shows to expressed metabolism disorder of aminoacids, intensified formation of ammonia in tissues and reduce of hepatocytes functional activity. Leucin/isoleucin coefficient is increased in 1,2 times that witnesses about disorder of protein synthesis. It was revealed that in all patients with vitiligo, not depending on intestine disbacteriosis, statistically reliable raise of above mentioned aminoacids and insignificant reduce of phenylalanine concentration, was marked. For the first time influences of blood aminoacid spectrum on activity and vitiligo process course were analysed, that gave possibility to approach purposefully to complex treatment, including therapeutic nutrition.

Practical value.  Practical health care was suggested the carried out scheme of treatment of children suffering from vitiligo with inclusion of therapeutic nutrition (diet 4b), that will take to a raise of therapy efficiency.

Key words: vitiligo in children aminoacids, metabolism disorder, disbacteriosis of intestine, therapeutic nutrition, pathogenetic treatment.

First page

536

Last page

543

For citation: Sobirov U.Yu. Rixsiev U.Sh., Mamadiev A.A., Yuldashev M.A. PROTEIN METABOLISM IN CHILDREN, SUFFERING FROM VITILIGO, DEPENDING ON MICROBIOCYNOSIS OF INTESTINE AND METHODS OF THIS CORRECTION //New Day in Medicine 2(34)2021 536-543 https://cutt.ly/SEkmxBN

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