31 -1 (29/1) 2020 — Adambaev Z.I., Ismailova M.O., — CLINICAL AND NEUROPHYSIOLOGICAL CHANGES IN PATIENTS WITH SYMPTOMATIC EPILEPSY OF VIRAL ETIOLOGY

CLINICAL AND NEUROPHYSIOLOGICAL CHANGES IN PATIENTS WITH SYMPTOMATIC EPILEPSY OF VIRAL ETIOLOGY

Adambaev Z.I., -Urgench branch of TMA and Neurological Clinic “Global Med System”, Tashkent.

Ismailova M.O., -Urgench branch of TMA and Neurological Clinic “Global Med System”, Tashkent.

Resume,

The aim of the study was to study the clinical and neurophysiological changes in patients with symptomatic epilepsy of viral etiology.

Material and methods. 90 patients with symptomatic epilepsy of viral etiology were examined.

Results: Attacks in symptomatic epilepsy of viral etiology are characterized by generalized (in 61.1%) and partial (in 38.9%) seizures. In 27.8% of patients, the first seizure occurs in the acute period of neuroinfection, and in the remaining 72.2% in the long-term period: from six months to 10 years. Symptomatic viral etiology of epilepsy during the course of the disease is divided into two types: favorable (63.3% of patients) and unfavorable (36.7%) – pharmacoresistant. On MRI images of the brain, hyperintensive foci of 1-3 mm in size were detected in the frontal, temporal and subcortical regions. In EEG studies, in patients with a favorable course of the disease, mainly acute slow-wave and spike slow-wave complexes were observed, and in patients with an unfavorable course (pharmacoresistant), in addition, multifocal and regional foci and hypsorrhythmia were observed. Conclusions: Herpes and CMV is the etiological basis for the development of symptomatic epilepsy, which determines the corresponding clinical and neurophysiological manifestations that must be taken into account in the diagnosis and treatment of this type of epilepsy.

Keywords: symptomatic epilepsy, neurophysiology, herpes, cytomegalovirus.

First page

114

Last page

116

For citation: Adambaev Z.I., Ismailova M.O., Clinical and neurophysiological changes in patients with symptomatic epilepsy of viral etiology//New Day in Medicine 1(29)2020 114-116 https://cutt.ly/UvKrUap

List of References

1. Карлов В. А. Фармакорезистентность и толерантность при эпи­лепсии. Эпилепсия. Под ред. Н. Г. Незнанова. СПб. 2010; Глава 26 (III): 730-741.
2. Крыжановская С.В., Шнайдер Н.А. Этиопатогенез хрониза- ции поражения центральной нервной системы при герпети­ческой инфекции // Вестник Клинической больницы №51. – 2010; 111(10): 38-48.
3. Ahmad A., Ramakrishna S., Meara J., Doran M. Autoimmune limbic encephalitis: a reversible form of rapidly progressive amnesia and seizures. J R Coll Physicians Edinb. 2010; 40: 123-5.
4. Armangue T., Petit-Pedrol M., Dalmau J. Autoimmune Encephalitis in Children. J Child Neurol. 2012; 27: 1460-1469.
5. Kennedy P.G.E., Chaudhuri A. Herpes simplex encephalitis // J. Neurol. Neurosurg. Psychiatry. – 2002. – Vol. 73(3). – P. 237-238.
6. Mohanraj R., Brodie M. J. Pharmacological outcome in early-diagnosed epilepsy. Epilepsy Behavior. 2005; 6: 382-387.
7. Vezzani A., French J., Bartfai T., Baram T.Z. The role of inflammation in epilepsy // Nat. Rev. Neurol. – 2011 – Vol. 7(1). – P. 31-40.
8. Yao K., Crawford J.R., Komaroff A.L. et al. Review part 2: Human herpesvirus-6 in central nervous system diseases // J. Med. Virol. – 2010. – Vol. 82(10). – P. 1669-1678.