27 -2 (30) 2020 — Ismatova M.N., Shadjanova N.S., — THE STATE OF THROMBOCYTIC LINK OF HEMOSTASIS IN CASE OF INSULIN RESISTANCE SYNDROME

THE STATE OF THROMBOCYTIC LINK OF HEMOSTASIS IN CASE OF INSULIN RESISTANCE SYNDROME

Ismatova M.N. -Bukhara state medical institute, Bukhara, Uzbekistan.

Shadjanova N.S. -Bukhara state medical institute, Bukhara, Uzbekistan.

Resume,

The significance of insulin resistance syndrome in the formation of platelet pathology of hemostasis was studied. The object of the study was 110 patients with metabolic syndrome. As comparison groups, 2 groups were identified (one – individuals without insulin resistance syndrome, the second group – patients with type 2 diabetes). The introduction into the diagnostic methods of hemostasis in the case of insulin resistance syndrome reduces the risk of the formation of cardiovascular diseases and the associated increased mortality of the population. The functional activity of platelets in violation of the sympathoadrenal and vaginal phases of the glycemic curve was studied.

Key words: insulin resistance, diabetes mellitus, hemostasis, glycemic curve, myocardial infarction.

First page

115

Last page

117

For citation: Ismatova M.N., Shadjanova N.S., The state of thrombocytic link of hemostasis in case of insulin resistance syndrome//New Day in Medicine 2(30)2020 115-117 https://cutt.ly/ccQbtOO

List of References

1. Diagnostic criteria for metabolic syndrome and insulin resistance in patients with obesity. / Belyakova NA, Lyasnikova MB, Tsvetkova IG, and others // Tver medical journal. 2015. No. 4. P. 1-15.
2. Endothelial dysfunction. Pathogenetic value, correction methods / Ed. H.H. Petrishchev. SPb. IIC BMA, 2007. — 296 p.
3. Endothelial dysfunction and impaired platelet-coagulation hemostasis in the development of diabetic nephropathy in type 2 diabetes mellitus / V.I. Sizikov et al. // Diabetes mellitus. 2007. – №1. – S. 4648.
4. Dontsov A.V., Vasilyeva L.V. Insulin resistance in metabolic syndrome as an indicator of cardiovascular risk. // Clinical medicine. 2016. V. 94. No. 3. P. 189-193.
5. Dulin P.A., Goryutsky V.N. Insulin resistance as one of the mechanisms of arterial hypertension formation. // Journal of scientific articles Health and education in the XXI century. 2014. V. 16. No. 4. P. 104-106.
6. Hundal R, Petersen K. Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. J Clin Densitom. 2002; 109:1321-1326. [PMC free article] [PubMed] [Google Scholar]
7. Anderson K, Wherle L, Park M, Nelson K, Nguyen LD. Salsalate, an old, inexpensive drug with potential new indications: a review of the evidence from 3 recent studies. Am Heal Drug Benefits. 2014; 7:231-235. [PMC free article] [PubMed] [Google Scholar]
8. Gerald Grandl, Christian Wolfrum/ Hemostasis, endothelial stress, inflammation, and the metabolic syndrome Semin Immunopathol. 2018; 40(2): 215-224. Published online 2017 Dec 5. doi: 10.1007/ s00281-017-0666-5