22 -2 (34/1) 2021 — Nazarova M.B., Adilbekova D.B. — MORRPOLOGICAL CONDITION OF GENERATIONS LIVER BORN UNDER CONDITIONS OF CHRONIC INTOXICATION OF THE MOTHERS ORGANISM

MORRPOLOGICAL CONDITION OF GENERATIONS LIVER BORN UNDER CONDITIONS OF CHRONIC INTOXICATION OF THE MOTHERS ORGANISM

Nazarova M.B., Urgench branch of the Tashkent Medical Academy Tashkent Medical Academy

Adilbekova D.B. Urgench branch of the Tashkent Medical Academy Tashkent Medical Academy

Resume

 Experiments have shown that chronic toxic hepatitis in the mother adversely affects the processes of postnatal growth, development and formation in the liver blood vessels and tissues of the offspring born from it. The pathomorphological changes that occur in the tissues and blood vessels of the azo lead to the development of processes that lag behind the development and formation in the later stages of postnatal development. These processes indicate the need to develop rational, science-based treatment and prevention measures in the treatment of the offspring born with existing pathology in the mother, the prevention of their diseases.

Key words: chronic toxic hepatitis, mother-offspring, hepatic vascular, tissue.

First page

124

Last page

128

For citation: Nazarova M.B., Adilbekova D.B. Morrpological condition of generations liver born under conditions of chronic intoxication of the mothers organisme //New Day in Medicine 2(34/1)2021 124-128 https://cutt.ly/QbRHY3E

LIST OF REFERENCES

1. Averyanov S.V., Chuikin L.A., Musina S.V. Morphological changes in the liver of kris under the influence of ecotoxicants during the antenatal period of development. (Ufa) // Morphological statements. .-2008.-№1.-S.203-205.
2. Bryusin G.V., Sizonenko M.L. The role of experimental damage to the mother’s liver in the development of physiological immaturity of offspring // Byull. experiment. biol. et med. – 2012. – T. 154, №. 11. – S. 544-547.
3. Bezrodnova S.M., Bondarenko G.M., Khorev O. Yu., Et al. Modern aspects of the introduction of hepatitis // Scientific Bulletin of Belgorod State University. Series: Medicine. Pharmacy.-2014.
4. Vakhnin V.A., Laskov D.S. Assessment of morphological and biological indicators of development in the offspring of rats females with lesions of the hepatobiliary system of various etiologies // Priority scientific directions.-theories 2016.-13.
5. Duduk N. Structural and Histoximic Changes in the Liver of 45-Day-Old Kris Offspring with Experimental Cholestasis / N.I. Duduk, S.M. Zimatkin // News of biomedical sciences. . – 2014. – Т.9, №1.–S. 49-53.
6. Duduk N. Correxia of morphofunctional changes in the liver of Kris offspring with experimental cholestasis / N.I. Duduk, R.I. Kravchuk, S.I. Zimatkin // VESSINAN Belarus. Medical Science Series. –2014. – № 3.– С. 78-83.
7. Iliniks M.A., Bryuksin G.V. Structurally functional formation of the pancreatic fluid of the offspring of an animal with chronic experimental lesions of the hepatobiliary system of various kinds. Chelyabinsk State Bulletin Pedagogical University. 2006; 4 (6): 113-123.
8. Matsyuk, J.R. Xolestasis pregnant and organogenesis of offspring (experimental study) / Ya.R. Matsuki et al. // Actual problems of medicine. In 2 parts: materials of the annual final scientific and practical conference. Crodno –2013.–Ч. I. – С. 61-64.
9. Sadovnikova V.V., Sadovnikova I.V., Ivanova N.L. Morphological changes in the liver of rats in toxic drug hepatitis and stimulation of reparative processes // Morphology. – 2001. – Т. 120, № 6. – S.63-65.
10. Sizonenko M.L., Bruksin G.V. Formation of the generative function of the testes of the offspring of rats females with chronic liver damage // Problems of reproduction. . – 2009. – № 1. – S. 16-19.
11. Ceccanti M., Attili A., Balducci G., et al. Acute alcoholic hepatitis // J. Clin. Gastroenterol. – 2006.–Vol.40, № 9. – P. 833-841.
12. Watson A.J. Duckworth C.A., Guan Y. and Montrose M.H. Mechanisms of epithelial cell shedding in the Mammalian intestine and maintenance of barrier function. Ann. N. Y. Acad. Sci., 2009, v. 1165, p. 135-142.
13. Yue W-f, Zhou F., Malik F. A. et al Demonstracion of protein absorption in the intestinal epithelium of fish and mice by laser scanning confocal microscopy. Biol. Chem., 2010, v. 391,
14. Auvinen К., Emmi Lokka , Mokkala Elias  et al. Fenestral diaphragms and PLVAP associations in liver sinusoidal endothelial cells are developmentally regulated //Sci Rep.- 2019 Oct 30;9(1):15698.
15. Barberá-Guillem E., Arrue J. M., Ballesteros J., Vidal-Vanaclocha F. Structural changes in endothelial cells of developing rat liver in the transition from fetal to postnatal life// J. Ultrastruct Mol Struct Res . Oct-Dec 1986; 97(1-3):197-206
16. Bhatia S.N. Underhill G.H., Zaret K.S., Fox I.J. Cell and tissue engineering for liver disease. //Sci Transl Med. 2014.- 6: 245 sr 242
17. Castrogiovanni P., Musumeci G., Trovato F.M., Avola R., Magro G., Imbesi R. Effects of high-tryptophan diet on pre- and postnatal development in rats: a morphological study.// Eur J Nutr. 2014 Feb; 53(1):297-308.
18. Kobayashi H., Yoshida S., Sun Y.J., Shirasawa N., Naito A. Postnatal development of gastric aromatase and portal venous estradiol-17β levels in male rats. //J Endocrinol. 2013 Jun. 1; 218(1):117-24
19. Lee S., Zhou P., Whyte S., Shin S. Adeno-associated virus serotype 8-mediated genetic labeling of cholangiocytes in the neonatal murine liver.-2020.-Pharmaceutics 12(4), 351
20. Ober E.A., Lemaigre F.P. Development of the liver: Insights into organ and tissue morphogenesis. //J Hepatol. 2018 May;68(5):1049-1062