178 -2 (30/4) 2020 — Akhmedov K. Ergashev M. — DYNAMICS OF ALTERATIONS OF LIVER MICROHEMOCIRCULATION IN EXPERIMENTAL EXTRACERAL CHOLESTASIS

DYNAMICS OF ALTERATIONS OF LIVER MICROHEMOCIRCULATION IN EXPERIMENTAL EXTRACERAL CHOLESTASIS

Akhmedov K., -Termez branch of Tashkent Medical Academy Uzbekistan, 132000, Surkhandarya region. Termez city, Islam Karimov street 64 houses.

Ergashev М., -Termez branch of Tashkent Medical Academy Uzbekistan, 132000, Surkhandarya region. Termez city, Islam Karimov street 64 houses.

Meliboboev А., -Termez branch of Tashkent Medical Academy Uzbekistan, 132000, Surkhandarya region. Termez city, Islam Karimov street 64 houses.

Pardaev E., -Termez branch of Tashkent Medical Academy Uzbekistan, 132000, Surkhandarya region. Termez city, Islam Karimov street 64 houses.

Resume,

This article presents the results of an experiment in microcirculatory changes in the liver with extrahepatic cholestasis. The experiments were carried out on 48 white outbred rats – males of a mixed population. Extrathepatic cholestasis was reproduced in rats by ligation of the common bile duct. As a result of the experiment, animals with ligation of the common bile duct revealed abnormalities in the system of peripheral blood circulation of the liver. Changes were manifested by a complex of intravascular, vascular and paravasal changes, a violation of liver angioarchitectonics, a marked increase in the area of dystrophic lesions of the parenchyma in the form of foci of posthemorrhagic organization. Violations of angioarchitectonics took a pronounced character, which was manifested by the practical destruction of the structure of the hepatic parenchyma, an increase in the area of “silent” zones in which blood flow was completely absent. As a result of the experiment, microcirculatory changes in the liver were found associated with a violation of the rheological properties of blood, and subsequently with the action of toxic metabolites of impaired metabolism.

Keywords: cholestasis, , microhemocirculation, angioarchitectonics.

First page

667

Last page

670

For citation: Akhmedov K., Ergashev М. Meliboboev А. Pardaev E., Dynamics of alterations of liver microhemocirculation in experimental extraceral cholestasis//New Day in Medicine 2(30)2020 667-670 https://cutt.ly/gvDmLA2

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