98 -3 (31/3) 2020 — Nishonova D.V., Holmatova N.O., — EFFECT OF GLUCOCORTICOID THERAPY ON FILTRATION AND EXTRACTING FUNCTION OF KIDNEYS IN TUBULOINTERSTITIAL NEPHRITIS IN CHILDREN
EFFECT OF GLUCOCORTICOID THERAPY ON FILTRATION AND EXTRACTING FUNCTION OF KIDNEYS IN TUBULOINTERSTITIAL NEPHRITIS IN CHILDREN
Nishonova D.V. -Andizhan state medical institute.
Holmatova N.O. -Andizhan state medical institute.
Resume
The article presents the results of the analysis of the effectiveness of hormone therapy in 17 children with tubulointerstitial nephritis. The patient group was divided on the basis of baseline plasma creatinine and followed for 6 months. All patients receiving hormonal therapy had normal plasma creatinine after a month of treatment, while this indicator returned to normal in 50% of patients who did not receive treatment. At the end of follow-up, a significant number of patients in both groups had subnormal GFR and/or persistent proteinuria. Ophthalmic complications were present in 82% of patients.
Key words: Tubulointerstitial nephritis, glucocorticoids, treatment, children.
First page
410
Last page
413
For citation: Nishonova D.V., Holmatova N.O., Effect of glucocorticoid therapy on filtration and extracting function of kidneys in tubulointerstitial nephritis in children//New Day in Medicine 3(31)2020 410-413 https://cutt.ly/PxD5ciJ
List of References
- Вялкова А.А. Актуальные проблемы тубулоитерстициальтого поражения почек у детей //Педиатрия. 2011.- Т.87.-№3.-С.122- 127.
- Длин В.В., Осматов И.М. Дисметаболическая тофропатия с оксалатто-кальциевой кристаллурией //Эффективная фармакотерапия. 2013.-№42.-С.8-16.
- Юрьева Э.А., Длин В.В., Кудин М.В. и др. Обменные тофро- патии у детей: причитог развития, клинико-лабораторные проявления //Рос. Вести. перинатол. и педиатр. 2016.-Т61.-№2.- С.28-34.
- Alon U.S. Tubulointerstitial nephritis. In: Pediatric nephrology, 6th edn. Springer, Berlin Heidelberg, 2012.-pp 1081-1098
- Eckardt K.U., Alper S.L., Antignac C. at all. Autosomal dominant tubulointerstitial kidney disease: diagnosis, classification, and management- A KDIGO consensus report //Kidney Int.-2015.- №88.-Р.676-683. [PubMed: 25738250]
- Jahnukainen T., Ala-Houhala M., Saarela V., Nuutinen M. Eye examination is important in patients with tubulointerstitial nephritis //Pediatr Nephrol. -2011.-№26.-Р.1179
- KDOQI clinical practice guidelines and clinical practice recommendations for diabetes and chronic kidney disease. National kidney foundation //Am. J. Kidney Dis.-2017.-V49.-№2.-P.180
- Lava S.A.G, Bucher O., Bucher B.S., Simonetti G.D., Tschumi S. Development of uveitis during systemic corticosteroid therapy in TINU syndrome //Pediatr Nephrol. -2012.-№26.-Р.1177-1178
- Mackensen F., David F., Schwenger V., Smith L.K., Rajalingam R., Levinson R.D. et all. HLA-DRB1-0102 is associated with TINU syndrome and bilateral, sudden-onset anterior uveitis but not with interstitial nephritis alone //Br. J. Ophthalmol.-^^95.-Р.971- 975
- Reddy A.K., Hwang Y.S., Mandelcorn E.D. et all. HLA-DR, DQ Class II DNA Typing in Pediatric Panuveitis and Tubulointerstitial Nephritis and Uveitis //Am.J.Ophthalmol.- 2014.V157.-P.678-686.
- Roupakias S., Sinopidis X., Tsikopoulos G. et all. Dimercaptosuccinic acid scan challenges in childhood urinary tract infection, vesicoureteral reflux and renal scarring investigation and management //Minerva Urol. Nefrol.-2017.- У.69.-№2.-Р.144-152.
- Saarela V., Nuutinen M., Ala-Houhala M. et all. Tubulointerstitial Nephritis and Uveitis Syndrome in Children: A Prospective Multicenter Study //Oph.thalmology.-2013.-№120.-Р.1476-14«1. [PubMed: 23511116]
- Saarela V., Nuutinen M., Jahnukainen T. Childhood tubulointerstitial nephritis and uveitis syndrome //CML Ophthalmol.-^^21.-Р.129-132
- Teeranai S., Goldman R.D. Corticosteroids for renal scar prevention in children with acute pyelonephritis //Canadian Family Physician.-^^63.-Р.286-287
- Ulinski T., Sellier-Leclerc A.L., Tudorache E. et all. Tubulointerstitial nephritis //Pediatr. Nephrol.-^^27.-Р.1051-1057
- Vervoot G., Willems H.L., Wetzels J.F. Assessment of glomerular filtration rate in healthy subjects and normoalbuminuric diabetic patients: validity of new (MDRD) prediction equation //Nephrol. Dial Transplant.-2012.-V17.-P.1909-1913.