174 -3 (31/4) 2020 — Akhmedov K.X. Ergashev M.A. — DYNAMICS OF ALTERATIONSOF LIVER MICROHEMOCIRCULATION IN EXPERIMENTAL EXTRACERAL CHOLESTASIS

DYNAMICS OF ALTERATIONSOF LIVER MICROHEMOCIRCULATION IN EXPERIMENTAL EXTRACERAL CHOLESTASIS

Akhmedov К.Х. -Termez branch of Tashkent medical academy.

Ergashev М.А. -Termez branch of Tashkent medical academy.

Meliboboev А. -Termez branch of Tashkent medical academy.

Pardaev Э.С. -Termez branch of Tashkent medical academy.

Resume

This article presents the results of an experiment in microcirculatory changes in the liver with extrahepatic cholestasis. The experiments were carried out on 48 white outbred rats – males of a mixed population. Extrathepatic cholestasis was reproduced in rats by ligation of the common bile duct. As a result of the experiment, animals with ligation of the common bile duct revealed abnormalities in the system of peripheral blood circulation of the liver. Changes were manifested by a complex of intravascular, vascular and paravasal changes, a violation of liver angioarchitectonics, a marked increase in the area of dystrophic lesions of the parenchyma in the form of foci of posthemorrhagic organization.Violations of angioarchitectonics took a pronounced character, which was manifested by the practical destruction of the structure of the hepatic parenchyma, an increase in the area of “silent” zones in which blood flow was completely absent. As a result of the experiment, microcirculatory changes in the liver were found associated with a violation of the rheological properties of blood, and subsequently with the action of toxic metabolites of impaired metabolism.

Keywords: cholestasis,, microhemocirculation, angioarchitectonics.

First page

713

Last page

717

For citation: Akhmedov К.Х., Ergashev М.А., Meliboboev А., Pardaev Э.С., Dynamics of alterationsof liver microhemocirculation in experimental extraceral cholestasis//New Day in Medicine 3(31)2020 713-717 https://cutt.ly/2xLdgQF

List of References

1. Голованова Е.В., Петраков А.В., Носкова К.К. Внутрииеченочный холестаз ири хронических заболеваниях печени. // Эксиеримекгалиая и клиническая гастроэнтерология. – 2011г. – №2. – С. 58-67.Golovanova E.V., Petrakov A.V., Noskova K.K. Intrahepatic cholestasis in chronic liver diseases. // Experimental and clinical gastroenterology. – 2011. – №2. – P. 58-67.
2. Зафирова В.Б. Клиническое и иатогенетическое значение на- рушений микроциркуляции и состояния эндотелиальных ме­диаторов ири хронических вирусных заболеваниях иечепи // Автореферат диссертации на соискание ученой стеиени кан­дидата медицинских наук, Пятигорск, 2011 г, e-3-4.Zafirova V.B. Clinical and pathogenetic significance of microcirculatory disorders and the state of endothelial mediators in chronic viral liver diseases // Abstract of dissertation for the degree of candidate of medical sciences, Pyatigorsk, 2011, P-3-4.
3. Зуфаров К.А., Са.дри.д.динов А.Ф. Склеротические изменения в иечепи ири эксиерименатльном холестазе и их обратимость иосле восстановления оттока желчи // Бюллетень эксиериментальной биологии и медицины, 1986, – т.52. – №7, с-105- 108.Zufarov K.A., Sadriddinov A.F. Sclerotic changes in the liver during experimental cholestasis and their reversibility after restoration of bile outflow // Bulletin of Experimental Biology and Medicine, 1986, – V.52. – №7, P-105-108.
4. Ирискулов Б.У. Нарушение реологических свойств крови и микроциркуляции внутренних орзанов ири эксиеримеитальном сахарном диабете // Диссертация на соискание учсной стеиени кандидата медицинских наук, Ташкент, 1993 г, с- 23.Iriskulov B.U. Violation of the rheological properties of blood and microcirculation of internal organs in experimental diabetes mellitus // The dissertation for the degree of candidate of medical sciences, Tashkent, 1993 г, P-23.
5. 0ахназарян Н.Г. Оитимизация методов лечения механической желтухи у больных с иатологией билиоианкреатодуоденальной зоны // Автореферат диссертации на соискание учсной стеиени кандидата медицинских наук Ставроиоль, 2014 г. С- 3.Shahnazaryan NG, Optimization of treatment methods for obstructive jaundice in patients with pathology of the biliopancreatoduodenal zone // Abstract of dissertation for the degree of candidate of medical sciences Stavropol, 2014, P-3
6. Hennenberg M, TrebickaJl, BieckerE et al.Vascular dysfunction in human and rat cirrhosis: Role of receptor-desensitizing and calcium-sensitizing proteins // Hepatology.-2007.- Vol. 45 (2).- P. 495 – 506.
7. Iwakiri Y, Groszmann RJ. The hyperdynamic circulation of chronic liver diseases; from the patient to the molecule // Hepatology.- 2006.- V.43 (2, suppl. 1).- P.121-131.
8. Iwakiri Y, Grisham M, Shah V. Vascular biology and pathobiology of the liver: Report of a single-topic symposium // Hepatology.- 2008.- Vol.47 (5).- P.1754-1763.
9. Yang Y-Y, Lee K-Ch, Huang Y-T et al. Effects of N-acetylcysteine administration in hepatic microcirculation of rats with biliary cirrhosis // J Hepatology.- 2008.- Vol.49 (1).- P.25 – 33.

174-713-717-3-31-2020-