98 -4 (32/3) 2020 — Yakhudaev E.M., Rakhmanova U.Kh. — IMPAIRMENT OF EPIDERMAL BARRIER REGULATION IN THE FORMATION OF ATOPIC DERMATITIS AND BRONCHIAL ASTHMA IN CHILDREN

IMPAIRMENT OF EPIDERMAL BARRIER REGULATION IN THE FORMATION OF ATOPIC DERMATITIS AND BRONCHIAL ASTHMA IN CHILDREN

Yakhudaev E.M. -Andijan State Medical Institute

Rakhmanova U.Kh. -Andijan State Medical Institute

Resume

The formation of bronchial asthma in children with atopic dermatitis is facilitated by the persistent course of atopic dermatitis, as well as the expansion of the spectrum of sensitization at the age of 4 to 6 years, which coincides with the time of manifestation of allergic rhinitis. In children with atopic dermatitis and bronchial asthma, there is a direct correlation between the severity of atopic dermatitis and the severity of bronchial asthma.

Severe bronchial asthma in children with atopic dermatitis over the age of 6 is more common in girls, as well as in patients who have undergone perinatal encephalopathy in infancy, suffering from chronic adenoiditis, chronic gastroduodenitis, disorder  of the autonomic nervous system, with signs of connective tissue dysplasia.

Children with combined allergic pathology and a family history of atopic dermatitis on the mother’s side are characterized by a persistent course of atopic dermatitis and the formation of its severe forms.

Key words: epidermal barrier, bronchial asthma, atopic dermatitis

First page

392

Last page

393

For citation: Yakhudaev E.M., Rakhmanova U.Kh., Impairment of epidermal barrier regulation in the formation of atopic dermatitis and bronchial asthma in children//New Day in Medicine 4(32)2020 392-393 https://cutt.ly/az2kNvo

List of References

1. Бикташева, JI.A. Мухтарова, Э.Р. Гуменная, P.P. Мурзнна, Р.Ф. Гатиятуллин, Ш.З. Загидуллин, Э.И. Эткина, Э.К. Хуснутди­нова // Медико-биологические аспекты мультифакториаль- ной патолоши: матер. II Всерос. науч.-практич. конф. с меж- дунар. участием. – Курск: КГМУ, 17-19 мая 2011. – С. 59-60.
2. Левашева, С.В. Нарушение эпидермального барьера в патоге­незе атопического дерматита у детей / С.В. Левашева, Г.Ф. Гималова, Ю.Ю. Федорова // Фундаментальная наука и кли­ническая медицина-человек и его здоровье: матер. XIV Все­рос. мед. -биол. конф. молодых исследователей с междунар. уча­стием. – СПб., 16 апреля 2011. – С. 152- 153.
3. Barnes KC. An update on the genetics of atopic dermatitis: scratching the surface in 2009. J Allergy Clin Immunol. 2010; 125(1):16-29.
4. Hachem JP Man MQ, Crumrine D, et al. Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity. J Invest Dermatol. 2005; 125(3):510-520.
5. Walley AJ, Chavanas S, Moffatt MF, et al. Gene polymorphism in Netherton and common atopic disease. Nat Genet. 2001; 29(2):175-178.

98-392-393-4-32-2020-тиббиёт-25-12-2020-—-копия