34 -3 (35) 2021 — Nuritdinov N.N. — STUDY OF CYP11B2 C (1799998) GENE POLYMORPHISM IN PATIENTS WITH CHRONIC HEART FAILURE

STUDY OF CYP11B2 C (1799998) GENE POLYMORPHISM IN PATIENTS WITH CHRONIC HEART FAILURE

Nuritdinov N.N. Tashkent Medical Academy, Uzbekistan

Resume

Analysis of the results on the study of the characteristics of the allelic polymorphism of the CYP11B2 gene (rs1799998) aldosterone synthase among CHF patients revealed a trend towards an increase in the number of T / T homozygotes of the rs1799998 locus of the CYP11B2 gene in the group of CHF patients with high odds ratios, indicating an increased risk of developing CHF. The mutant T / T genotype of the CYP11B2 gene polymorphism (rs1799998) can be considered as an independent genetic marker associated with severe renal dysfunction accompanied by a significant decrease in GFR in CHF patients.

Key words: chronic heart failure, gene polymorphism, renal dysfunction

First page

182

Last page

186

For citation: Nuritdinov N.N. STUDY OF CYP11B2 C (1799998) GENE POLYMORPHISM IN PATIENTS WITH CHRONIC HEART FAILURE //New Day in Medicine 3(35)2021 182-186 https://cutt.ly/gWMlhvE

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