19 -2 (64) 2024 - Giyosova N.O. - MODERN MARKERS OF DIAGNOSTIC CHRONIC KIDNEY DISEASES

MODERN MARKERS OF DIAGNOSTIC CHRONIC KIDNEY DISEASES

Giyosova N.O. Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Scientific studies conducted worldwide have shown that hypertension is the most common comorbidity associated with COVID-19, confirming that it occurs in 10–34% of cases. Their combination leads to severe complications not only of COVID-19, but also of arterial hypertension, including kidney damage. The article presents the results of a study of modern approaches to the early diagnosis of nephropathies caused by the above diseases.

Keywords: COVID-19, uromodulin, arterial hypertension, nephropathy, type IV collagen, post-Covid syndrome.

First page

128

Last page

132

For citation: Giyosova N.O. MODERN MARKERS OF DIAGNOSTIC CHRONIC KIDNEY DISEASES//New Day in Medicine 2(64)2024 128-132 https://newdayworldmedicine.com/en/article/3758

List of References

  1. Muchmore AV, Decker JM. Uromodulin: a unique 85-kilodalton immunosuppressive glycoprotein isolated from urine of pregnant women. // Science 1985;229(4712):479–481. doi: 10.1126/science.2409603
  2. Kottgen A, Pattaro C, Boger CA et al. New loci associated with kidney function and chronic kidney disease. // Nat Genet 2010;42(5):376–384. doi: 10.1038/ng.568
  3. El-Achkar TM, Wu XR. Uromodulin in kidney injury: an instigator, bystander or protector? // Am J Kidney Dis 2012;59(3):452–461. doi: 10.1053/j.ajkd.2011.10.054
  4. Wu TH, Li KJ, Yu CL, Tsai CY. Tamm-Horsfall Protein is a Potent Immunomodulatory Molecule and a Disease Biomarker in the Urinary System. // Molecules 2018;23(1).pii:E200. doi: 10.3390/ molecules23010200
  5. Смирнов АВ, Хасун М, Каюков ИГ и др. Уромодулин сыворотки крови как ранний биомаркер атрофии канальцев и интерстициального фиброза у пациентов с гломерулопатиями. // Тер арх 2018;90(6):41–44. doi: 10.26442/terarkh201890641-47
  6. Tamm I, Horsfall FL. Characterization and separation of an inhibitor of viral hemagglutination present in urine. // Proc Soc Exp Biol Med 1950;74(1):106–108
  7. Tamm I, Horsfall FL. A mucoprotein derived from human urine which reacts with influenza, mumps, and Newcastle disease viruses. // J Exp Med 1952;95(1):71–97. doi: 10.1084/jem.95.1.71
  8. Pennica D, Kohr WJ, Kuang WJ et al. Identification of human uromodulin as the Tamm-Horsfall urinary glycoprotein. // Science 1987;236(4797):83–88. doi: 10.1126/science.3453112
  9. Micanovic R, LaFavers K, Garimella PS et al. Uromodulin (Tamm-Horsfall protein): guardian of urinary and systemic homeostasis. // Nephrol Dial Transplant 2019; Jan 14. doi: 10.1093/ndt/gfy394
  10. Akhmedova N.Sh. Sulaуmonova G.T. Early diagnosis of Podocytic Dysfunction and Tubulointerstitial processes with hypertension and diabetes mellitius // Asian journal of Pharmaceutical and biological research. Sept-Dec 2021;10(3):177-183.
  11. Akhmedova N.Sh., Sulaуmonova G.T., Boltayev K.J. Prognostic significance of biomarkers in the early diagnosis of nephropathy in type II diabetes // Journal of Pharmaceutical Negative Results – 2022;13(10):118-1191. Scopus
  12. Boltayev K. J.; Ruziyev Z. M.; Ulug’ova Sh. T. Features changes in the hemostasis system in patients with COVID-19. Web. of. Sci. 2022;3:479-486.
  13. Болтаев К. Ж., Ахмедова Н. Ш. Характеристика феномена развития полидефицитных состояний при старении // Проблемы биологии и медицины. 2020;1:24-26.
  14. Boltayev K., Shajanova N. Anemia associated with polydeficiency in elderly and senile people // Galaxy International Interdisciplinary Research Journal. 2022;10(2):688-694.
  15. Болтаев К. Ж., Мирзоева М. Р. Особенности течения анемии у больных с хроническими вирусными гепатитами // Вестник Башкирского государственного медицинского университета. 2019;1:55-61.
  16. Гиёсова Н.О. Взаимодействие сердечно-почечного континуума в развитии нефропатии // Oriental Renaissance: Innovative, educational, natural and social sciences 597-606. 2022.
  17. Giyosova N.O. Modern diagnostic markers of nephropathy in patients with arterial hypertension and diabetes mellitus // Web of scientist: international scientific research journal.. Nov., 2022;3(11):142-150.
  18. Giyosova N.O. Nurov B.B. Course and therapy of arterial hypertension in patients with covid-19 // Web of scientist: international scientific research journal. Dec., 2022;3(12):1142-1149.
  19. Ахмедова Н.Ш., Гиёсова Н.О. Буйрак функционал заҳирасини аниқлаш - сурункали буйрак касалликлари эрта диагностикасида предиктор сифатида // Journal of Cardiorespiratory Research. Материалы II международной научно-практической конференции (Самарканд, 7-8 апрель 2023 г) Том II
  20. Giyosova N.O. Uromodulin as an early marker in the diagnosis of chronic kidney disease // Asian journal of Pharmaceutical and biological research. May-aug.2023;12:42-49.

    file

    download