26 -2 (64) 2024 - Bahronov J.J. - COMPARATIVE MORPHOLOGY OF KIDNEY AND NEPHRON STRUCTURES OF RATS RECEIVED PACLITAXEL AND POMEGRANATE OIL AND TREATED WITH A TRADITIONAL MEDICINE AFTER CHEMOTHERAPY FOR BREAST CANCER

COMPARATIVE MORPHOLOGY OF KIDNEY AND NEPHRON STRUCTURES OF RATS RECEIVED PACLITAXEL AND POMEGRANATE OIL AND TREATED WITH A TRADITIONAL MEDICINE AFTER CHEMOTHERAPY FOR BREAST CANCER

Bahronov J.J. Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

The carcinogen used in the experiments is 7,12-dimethylbeanthracene (DMBA), an oncogenic polycyclic aromatic hydrocarbon (PAH), C20H16. In recent decades, the increase in the number of cancer diseases requires the development of new drugs and methods of influencing tumor cells, and in some cases, strengthening of chemotherapy regimens. Despite the progress made in the treatment of tumor diseases, treatment toxicity is a huge problem. Paclitaxel chemotherapy drugs are mitosis inhibitors, block cell division, disrupt the function of microtubules and some enzyme proteins, and also change the metabolism of amino acids and some other substances, such as nucleic acids, lipid synthesis, and affect cellular respiration. Pomegranate seed oil, due to its antioxidant properties, is actively involved in the fight against free radicals and reduces the tissue-damaging effects of cancer chemotherapy. Timalin restores the remaining immunological reactivity, stimulates the processes of regeneration and hematopoiesis in the case of tissue regeneration, and also improves the activity of metabolic processes in cells.

Keywords: cancer, carcinogen, DMBA, PAН, chemotherapy, sarcomas, application.

First page

168

Last page

178

For citation: Bahronov J.J. COMPARATIVE MORPHOLOGY OF KIDNEY AND NEPHRON STRUCTURES OF RATS RECEIVED PACLITAXEL AND POMEGRANATE OIL AND TREATED WITH A TRADITIONAL MEDICINE AFTER CHEMOTHERAPY FOR BREAST CANCER//New Day in Medicine 2(64)2024 168-178 https://newdayworldmedicine.com/en/article/3758

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