36 -2 (64) 2024 - Egamova Sitora Kobilovna - INTERRELATION OF GENETIC ABNORMALITIES AND IMMUNOPHENOTYPIC FEATURES OF BLAST CELLS IN ACUTE MYELOID LEUKEMIA

INTERRELATION OF GENETIC ABNORMALITIES AND IMMUNOPHENOTYPIC FEATURES OF BLAST CELLS IN ACUTE MYELOID LEUKEMIA

Egamova Sitora Kobilovna Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

The characteristic immunophenotypes of acute myeloid leukemia with the most common genetic aberrations according to the classification of the World Health Organization (2008) are shown. Cases of acute myeloid leukemia are presented, which immunophenotypic features specified in presence of concrete recurrent abnormalities. So, detection in a bone marrow patient population blast myeloid cells with immunophenotype CD117+++, CD34+++, HLA-DR+++, CD38+++, суМРО+++, CD13dim, CD33dim, CD56+, CD19dim, CD7dim has allowed to assume availability translocation t(8;21). In other patient 2 populations of leukemia blasts were found out: 1) mature сells with high expression of antigens CD34, CD117, with features granulocytic differentiation; 2) more mature cells, not expressing CD34, CD117, with differentiation signs to direction monocytopoiesis and granulocytopoiesis with co expression antigen CD2, that indicated in damages to 16 chromosome (inv(16) or t(16;16)). In the third case population of blasts with bright homogeneous expression the pan-myeloid of antigen CD33, weak expression the pan-myeloid of antigen CD13 and early myeloid marker CD117, a positive expression of antigens CD9,CD64, cyMPO and negative on expression HLA-DR is found out, has given the possibility to predict presence t(15;17). In all cases, the supposition has been proved by cytogenetic analysis.

Keywords: acute myeloid leukemia, aberrant immunophenotype, flow cytometric, immunophenotypic analysis.

First page

240

Last page

244

For citation: Egamova Sitora Kobilovna INTERRELATION OF GENETIC ABNORMALITIES AND IMMUNOPHENOTYPIC FEATURES OF BLAST CELLS IN ACUTE MYELOID LEUKEMIA//New Day in Medicine 2(64)2024 240-244 https://newdayworldmedicine.com/en/article/3758

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