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  • 39 -2 (64) 2024 - R.K. Dadabaeva - THE ROLE OF THE GLY482SER POLYMORPHISM OF THE PPARGC1A GENE IN OBESE WOMEN OF CHILDBEARING AGE

39 -2 (64) 2024 - R.K. Dadabaeva - THE ROLE OF THE GLY482SER POLYMORPHISM OF THE PPARGC1A GENE IN OBESE WOMEN OF CHILDBEARING AGE

THE ROLE OF THE GLY482SER POLYMORPHISM OF THE PPARGC1A GENE IN OBESE WOMEN OF CHILDBEARING AGE

R.K. Dadabaeva Tashkent Medical Academy

Resume

The world's obese population has reached 700 million people and continues to increase steadily (Y.R.Timasheva et al., 2021). An increase in the prevalence of obesity, including in women of fertile age, is associated with the action of external and behavioral factors, which leads to stigmatization of people with obesity, since their problems are considered to be caused by an improper lifestyle, diet and other controlled factors. Nevertheless, the existence of a hereditary predisposition to obesity, which has a pronounced polygenic character, has been established. Mutations that have a significant effect on energy metabolism and fat deposition can lead to the development of obesity, but they are not detected in most patients. The low diversity of microbiome genes correlates with metabolic disorders (chronic inflammation, insulin resistance, glycemia and lipid disorders). The review presents the results of studies on the clinical, metabolic and genetic characteristics of Uzbek women of childbearing age who are obese, proving the genetic nature of the disease and creating prerequisites for identifying potential targets for drug therapy and developing personalized effective approaches in the diagnosis, treatment and prevention of obesity.

Keywords: women of childbearing age, metabolically healthy obesity, metabolically complicated obesity, gene polymorphism

First page

257

Last page

264

For citation: R.K. Dadabaeva THE ROLE OF THE GLY482SER POLYMORPHISM OF THE PPARGC1A GENE IN OBESE WOMEN OF CHILDBEARING AGE//New Day in Medicine 2(64)2024 257-264 https://newdayworldmedicine.com/en/article/3758

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