69 -2 (64) 2024 - Sh.Sh. Kadirov, G.A. Khakimov - RESULTS OF REAL CLINICAL PRACTICE OF COLON TREATMENT IN TASHKENT CITI

RESULTS OF REAL CLINICAL PRACTICE OF COLON TREATMENT IN TASHKENT CITI

Sh.Sh. Kadirov Tashkent Pediatric Medical Institute, Tashkent City Branch of the Republican Specialized Scientific Practical Medical Center of Oncology and Radiology Uzbekistan

G.A. Khakimov Tashkent Pediatric Medical Institute, Nano Medical Clinic; Uzbekistan, Tashkent City Branch of the Republican Specialized Scientific Practical Medical Center of Oncology and Radiology Uzbekistan

G.G. Khakimova Tashkent Pediatric Medical Institute, Nano Medical Clinic; Uzbekistan, Tashkent City Branch of the Republican Specialized Scientific Practical Medical Center of Oncology and Radiology Uzbekistan

H.I. Jumaniyozov Tashkent Pediatric Medical Institute, Tashkent City Branch of the Republican Specialized Scientific Practical Medical Center of Oncology and Radiology Uzbekistan

Sh.G. Khakimova Tashkent Pediatric Medical Institute, Nano Medical Clinic; Uzbekistan, Tashkent City Branch of the Republican Specialized Scientific Practical Medical Center of Oncology and Radiology Uzbekistan

HA. Saloxiddinov Tashkent Pediatric Medical Institute, Tashkent City Branch of the Republican Specialized Scientific Practical Medical Center of Oncology and Radiology Uzbekistan

Resume

Aim: To study the state of oncology care for patients with CC in the Tashkent city branch of the Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology (TCB RSSPMCOR). Materials and methods: According to the retro- and prospective analysis, from 2015 to 2022, 250 patients with colon cancer received treatment at the TCB RSSPMCOR. Of these, stage II 24% (n=61), stage III 47% (n=117), stage IV 29% (n=72). The average age is 59.29.9 years. The lesion of the left intestines prevailed (72.8% versus 37.2%), regardless of the stage. Histologically adenocarcinoma, G2 (97%). Of the 250 patients, 12.4% (n=31) received complex treatment, 55.2% (n=138) combined treatment, 32.4% (n=81) conservative treatment. Surgical treatment was performed in 58% (n=145), colostomy removal in 6.4% (n=16), surgical treatment and colostomy in 10% (n=25). 25.6% (n=64) remained without surgery. Radiation therapy was performed in 12% (n=30) in the pre- or postoperative regime, which amounted to (8% (n=20) vs. 4% (n=10), respectively). Targeted therapy was received by 10% (n=26). Chemotherapy was performed in 99% (n=248) cases. Of these: neoadjuvant - 15.6% (n=39), postoperative - 36.4% (n=91), perioperative - 16% (n=40), palliative - 31.2% (n=78). Results: In the structure of morbidity and mortality in the Republic of Uzbekistan, CC ranks 5th and 4th, respectively. During the follow-up period (mean 26.4±16.0 months, from 1 to 75 months, median 24.2 months), mortality was 145 (58.0%), progression rate was 220 (88.0%). Increasing the stage worsened overall survival (OS) and progression-free survival (PFS). Two-year OS for stages II, III and IV was 69.7% (median 36.9 months), 63.2% (median 28.4 months) and 21.9% (median 16.9 months), p = 0.000001 respectively.2-year PFS for stages II, III and IV was 52.8% (median 25.0 months), 30.3% (median 18.9 months) and 3% (median 9.5 months), p = 0, 00001 respectively. Conclusion: The analysis of statistical information showed that CC is one of the leading pathologies in the structure of oncology morbidity and mortality in Uzbekistan. There has been a steady increase in morbidity and mortality from CC. Taking into account the neglect of the stage at the initial detection of the tumor, the issues of diagnosing CC in the early stages remain relevant, and the treatment of CC requires compliance with international standards for the treatment of this pathology.

Keywords: colon cancer, overall survival, progression-free survival.

First page

433

Last page

440

For citation: Sh.Sh. Kadirov, G.A. Khakimov G.G. Khakimova, H.I. Jumaniyozov, Sh.G. Khakimova, .HA. Saloxiddinov - RESULTS OF REAL CLINICAL PRACTICE OF COLON TREATMENT IN TASHKENT CITI//New Day in Medicine 2(64)2024 433-440 https://newdayworldmedicine.com/en/article/3758

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