43 -3 (35) 2021 — Daminova K.M. — DIAGNOSTIC VALUE OF THE METHOD FOR DETERMINING GFR IN PATIENTS WITH CKD UNDER THE CONDITIONS OF THE PRIMARY LINE OF HEALTH CARE

DIAGNOSTIC VALUE OF THE METHOD FOR DETERMINING GFR IN PATIENTS WITH CKD UNDER THE CONDITIONS OF THE PRIMARY LINE OF HEALTH CARE

Daminova K.M. Tashkent State Dental Institute, Tashkent Uzbekistan

Resume,

The article presents the results of observation of 217 patients with CKD with various stages in the primary health care setting, among whom there were 110 men (50.69%), and 107 women (49.31%). The age of the patients varied from 18 to 65 years. All patients were tested for cystatin C by the immunoturbidimetric method, and creatinine was determined by the kinetic test using the Creatinine FS reagent (Dia Sys Germany). Total protein, albumin and urea were analyzed by the enzymatic method. Microalbuminuria (MAU) was determined semi-quantitatively using MicroalbuFAN strips. The results of the study indicate the advantage of determining the level of GFR by the indicator of cystatin C. However, given the conduct of this study in the conditions of primary health care, due to the lack of reliability of the results, as well as the more availability of the method for measuring the level of GFR by creatinine, its use is recommended.

Key words: Chronic kidney disease, cystatin C, creatinine, albumin, GFR, primary health care.

First page

224 

Last page

227 

For citation: Daminova K.M. DIAGNOSTIC VALUE OF THE METHOD FOR DETERMINING GFR IN PATIENTS WITH CKD UNDER THE CONDITIONS OF THE PRIMARY LINE OF HEALTH CARE //New Day in Medicine 3(35)2021 224-227 https://cutt.ly/eEq7rXK

LIST OF REFERENCES:

1. Averyanov S.N., Amcheslavsky V.G., Bagaev V.G., Tepaev R.F.  Determination of glomerular filtration rate in children: history and modern approaches.  //Pediatric Pharmacology.  2018; 15 (3): 218-223.  doi: 10.15690 / pf.v15i3.1901;
2. Daminova K.M., Babazhanova N.R.  Chronic kidney disease.  Educational methodical manual.  Tashkent 2021.
3. Kayukov I.G., Smirnov A.V., Emanuel V.L.  Cystatin C in modern medicine // Nephrology.  – 2012. – T.16.  – No. 1 – S. 22-39.  [Kayukov IG, Smirnov AV, Emanuel VL.  Cystatin C in current medicine.  Nephrology.  2012; 16 (1): 22-39.
4. Nahuel R.T., Detereva O.A., Kayukov I.G. et al.  On the problem of assessing the value of the glomerular filtration rate in patients with chronic kidney disease.  //Nephrology. – 2011 – T.15.  – No. 1 – P. 104-110
5. Smirnov AV, Kayukov IG, Yesayan AM et al. The problem of assessing the glomerular filtration rate in modern nephrology: a new indicator – cystatin S. //Nephrology 2005;  9 (3): 16-27
6. Tomilina N.A., Bikbov B.T.  The state of replacement therapy in chronic renal failure in Russia in 1998–2011.  (according to the register of the Russian Dialysis Society).  Bulletin of Transplantology and Artificial Organs.  2015; 17 (1): 35-58.  https://doi.org/10.15825/1995-1191-2015-1-35-58
7. Filler G., Priem F., Lepage N., Sinha P., Vollmer I., Clark H. et al.  Beta-trace protein, cystatin C, beta (2) -microglobulin and creatinine compared for detecting impaired glomerular filtration rates in children.  //Clin.  Chem.  2002; 48: 729-36.
8. Hojs R, Bevc S, Ekart R, Gorenjak M, Puklavec L. Kidney function estimating equations in patients with chronic kidney disease.  //Int J Clin Pract 2011;  65 (4): 458-464
9. Johnson K.R.  Strengths and weaknesses of renal markers as risk factors and surrogate markers.  //Kidney Int.  2011; 79: 1272-4.
10. National Kidney Foundation KD: Clinical practice guidelines for chronic Kidney disease: Evaluation, classification and stratification.  //Am J Kidney Dis 2002: 39 [Suppl 1]: S1-S266
11. Schiepati A, Remuzzi G, Chronic renal diseases as a public health problem: epidemiology, social, and economic implications.  //Kidney Int Suppl.  2005 Sep; (98): S7-S10.