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  • 35 -3 (65) 2024 - Khamdamova M.T., Teshaev Sh.Zh. - MORPHOLOGICAL CHANGES IN THE THYMUS AND SPLEEN IN RENAL FAILURE IN RATS AND CORRECTION WITH POMEGRANATE SEED OIL

35 -3 (65) 2024 - Khamdamova M.T., Teshaev Sh.Zh. - MORPHOLOGICAL CHANGES IN THE THYMUS AND SPLEEN IN RENAL FAILURE IN RATS AND CORRECTION WITH POMEGRANATE SEED OIL

MORPHOLOGICAL CHANGES IN THE THYMUS AND SPLEEN IN RENAL FAILURE IN RATS AND CORRECTION WITH POMEGRANATE SEED OIL

Khamdamova M.T. Bukhara State Medical Institute named after Abu Ali ibn Sina

Teshaev Sh.Zh. Bukhara State Medical Institute named after Abu Ali ibn Sina

Khikmatova M.F. Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Laboratory rats were exposed to salt water, which is known to be toxic to the kidneys. After confirming the development of kidney failure in rats, a study was conducted on the effectiveness of pomegranate seed oil, which was provided to them as a dietary supplement over a certain period of time. Rats exposed to salt water showed signs of kidney failure, such as increased creatinine and urea levels in the blood, as well as changes in the morphology of kidney tissue. When adding pomegranate seed oil to the diet of rats, an improvement in kidney function was observed, which was confirmed by a decrease in the biochemical parameters of creatinine and urea in the blood, as well as an improvement in the histological characteristics of the kidney tissue. Pomegranate seed oil shows potential in correcting salt water-induced renal failure in rats under experimental conditions. These results may indicate the possibility of using pomegranate seed oil as a potential therapeutic agent for the treatment or prevention of kidney diseases in humans.

Keywords: salts, kidney, pressure, pomegranate oil, kidney stones, sodium, spleen, thymus, morphology.

First page

176

Last page

187

For citation: Khamdamova M.T., Teshaev Sh.Zh., Khikmatova M.F. - MORPHOLOGICAL CHANGES IN THE THYMUS AND SPLEEN IN RENAL FAILURE IN RATS AND CORRECTION WITH POMEGRANATE SEED OIL//New Day in Medicine 3(65)2024 176-187 https://newdayworldmedicine.com/en/article/3758

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