54 -3 (65) 2024 - Boboev K.T., Musashaykhova Sh.M. - POLYMORPHIC LOCUS (rs1042522) TP53 AS AN EARLY PROGNOSTIC MARKER OF ACUTE MYELOID LEUKEMIA IN YOUNG PATIENTS

POLYMORPHIC LOCUS (rs1042522) TP53 AS AN EARLY PROGNOSTIC MARKER OF ACUTE MYELOID LEUKEMIA IN YOUNG PATIENTS

Boboev K.T. Republican Specialized Scientific and Practical Medical Hematology Center, Uzbekistan Tashkent

Musashaykhova Sh.M. Andijan State Medical Institute

Musashaykhov Х.Т. Andijan State Medical Institute

Sattarov O.X. Andijan State Medical Institute

Resume

In 117 patients under 60 years of age, the prediction of acute myeloid leukemia was analyzed by examining the frequency of distribution of the polymorphic marker Pro72Arg in the TP53 gene, which made up the main group. The control group consisted of 90 "conditionally healthy" individuals. Clinical and laboratory studies were performed at the Republican Specialized Scientific and Practical Medical Center of Hematology of the Ministry of Health of the Republic of Uzbekistan. The TР53 polymorphism was tested on a Rotor-Gene Q device (Quagen, Germany), using a commercial test kit from Syntol LLC (Russia).

Keywords: p Pro72Arg polymorphism, TP53 genetic marker, acute myeloid leukemia, DNA, genotype, allele, hyperleukocytosis, anemia.

First page

290

Last page

293

For citation: Boboev K.T., Musashaykhova Sh.M. Musashaykhov Х.Т., Sattarov O.X. - POLYMORPHIC LOCUS (rs1042522) TP53 AS AN EARLY PROGNOSTIC MARKER OF ACUTE MYELOID LEUKEMIA IN YOUNG PATIENTS//New Day in Medicine 3(65)2024 290-293 https://newdayworldmedicine.com/en/article/3758

List of References

1. Алланазарова Б.Р., Ассесорова Ю.Ю., Болтаева Ю.Ю. Модифицирование стандартного цитогенетического исследования для выявления хромосомных нарушений / Нововведения в лечении и профилактике заболеваний системы крови и проблемы трансфузиологии. – Ташкент 2013; 18-19.
2. Блау О.В. Мутации генов при острых миелоидных лейкозах. // Клиническая онкогематология. 2016; 9(3):245-56.
3. Гильмияров Э.М., Гильмиярова Ф.Н., Селезнева И.А., Свечникова М.В. и др. Способ прогнозирования проявлений стоматита у пациентов с острыми лейкозами по изменению содержания антител к трансглутаминазе классов иммуноглобулинов A и G в ротовой жидкости. / Патент РФ № 2572696. 2016
4. Грицаев С.В., Мартынкевич И.С. Возраст и кариотип — факторы риска у больных первичным острым миелоидным лейкозом. // Клиническая онкогематология. 2010; 3(4):359-65.
5. Amadou A, Waddington Achatz MI, Hainaut P. Revisiting tumor patterns and penetrance in germline TP53 mutation carriers: temporal phases of Li-Fraumeni syndrome. // Curr Opin Oncol. 2018; 30:23-29.
6. Burnatt G., Licínio M.A., Gaspar P.C., Ferreira A.S., Reis M.L., Moraes A.C.R.d., Sincero T.C.M., Santos-Silva M.C. Analysis of the presence of FLT3 gene mutation and association with prognostic factors in adult and pediatric acute leukemia patients. // Brazilian J. Pharmaceut. Sci. 2017;53(2).
7. Calderaro J, et al. Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification. // J. Hepatol. 2017; 67:727–738.
8. Creutzig U, Zimmermann M, Reinhardt D, et al. Changes in cytogenetics and molecular genetics in acute myeloid leukemia from childhood to adult age groups. // Cancer. 2016; 122:3821-3830
9. Daver N, Schlenk RF, Russell NH, Levis MJ. Targeting FLT3 mutations in AML: review of current knowledge and evidence. // Leukemia. 2019; 33(2):299–312.
10. Faber ZJ, Chen X, Gedman AL, et al. The genomic landscape of core-binding factor acute myeloid leukemias. // Nat Genet. 2016; 48:1551-1556.

    file

    download