63 -3 (65) 2024 - Imaeva L.R., Khunafina D.Kh. - COMPARATIVE ANALYSIS OF CLINICAL MANIFESTATIONS OF HEMORRHAGIC FEVER WITH RENAL SYNDROME AND HEMOLYTIC-UREMIC SYNDROME IN CHILDREN

COMPARATIVE ANALYSIS OF CLINICAL MANIFESTATIONS OF HEMORRHAGIC FEVER WITH RENAL SYNDROME AND HEMOLYTIC-UREMIC SYNDROME IN CHILDREN

Imaeva L.R. Federal State Budgetary Educational Institution of Higher Education BSMU of the Ministry of Health of Russia Republic of Bashkortostan

Khunafina D.Kh. Federal State Budgetary Educational Institution of Higher Education BSMU of the Ministry of Health of Russia Republic of Bashkortostan

Akhmetshin R.Z. Federal State Budgetary Educational Institution of Higher Education BSMU of the Ministry of Health of Russia Republic of Bashkortostan

Valeeva D.S. Federal State Budgetary Educational Institution of Higher Education BSMU of the Ministry of Health of Russia Republic of Bashkortostan

Resume

Relevance. Typical hemolytic uremic syndrome (HUS) and hemorrhagic fever with renal syndrome (HFRS) in children, as a result of systemic damage to the endothelium of small vessels, are characterized by the rapid development of similar polymorphic clinical manifestations, including acute kidney injury (AKI), which makes differential diagnosis and treatment of these nosologies. Timely detection of HUS and HFRS in children, as well as proper pathogenetic treatment, provide a favorable prognosis for these diseases. Target. To make a comparative assessment of the severity of HFRS and typical HUS in children to prescribe adequate pathogenetic treatment. Materials and methods of research. A comparative study was carried out on 63 children with HFRS and HUS who were hospitalized at the Republican Children's Clinical Hospital (Ufa). The first group of patients consisted of 32 children with HFRS complicated by AKI. The second group (comparison group) included 31 children with HUS as a result of acute intestinal infection. Results. The course of HFRS and HUS in children is similar to the acute onset, the presence of abdominal, hemorrhagic syndromes, and acute kidney damage. But boys (65.6%), 12-17 years old (46.9%) were most often susceptible to HFRS. Typical HUS was more common in girls (58%), under 2 years of age (77%). According to our data, the acute period of GUS, in contrast to GLPS, is characterized by significantly more severe kidney damage, requiring renal replacement therapy (ZPT) in half of the cases, expressed paternal syndrome (81%), arterial hypertension (58%), macrohematuria (42%). ), porazheniem TsNS (58%), convulsions (16%), razvitiem jizneugrojaemyx oslojneniy: syndrome of polyorgan noy deficiency (35%), acute cardiac deficiency (16%), edema of the brain (6.5%). The most frequently encountered symptoms of GLPS, and GUS, were: fever (100%), bradyarrhythmia (65.6%), heart failure (94%), heart failure (100%), chest hemorrhage ( 59%), blood circulation and sclera (12.5%). In 1 case (3.1%) - a 14-year-old girl with GLPS developed oslojnenie and vide ostrogo thrombosis glubokikh ven pravoy nijney nechnosti. Zaklyuchenie. Takim obrazom, nesmotrya na obshchnost otdelnyx zvenev pathogenesis, skhojest polymorphnyx klinicheskikh yayavleniy debut of typical GUS and oligoanuricheskogo period GLPS u detey, imeyutsya otlichitelnye dlya kajdoy iz etix nozologiy kliniko-laboratornye osobennosti. A carefully collected epidemiological anamnesis, revealing characteristic clinical and laboratory manifestations of GUS and GLPS, a multidisciplinary medical approach, timely diagnostic and therapeutic interventions, lead to favorable outcomes and severe pain in children.

Keywords: hemorrhagic fever with renal syndrome, hemolytic-uremic syndrome, children, acute kidney injury.

First page

336

Last page

344

For citation: Imaeva L.R., Khunafina D.Kh., Akhmetshin R.Z., Valeeva D.S. - COMPARATIVE ANALYSIS OF CLINICAL MANIFESTATIONS OF HEMORRHAGIC FEVER WITH RENAL SYNDROME AND HEMOLYTIC-UREMIC SYNDROME IN CHILDREN//New Day in Medicine 3(65)2024 336-344 https://newdayworldmedicine.com/en/article/3758

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