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60 -3 (35) 2021 — Nabiyeva Nozima Abdurakhimovna — NEUROIMMUNE INTERACTIONS AND CYTOKINE LEVELS IN CHILDREN WITH CEREBRAL PALSY

NEUROIMMUNE INTERACTIONS AND CYTOKINE LEVELS IN CHILDREN WITH CEREBRAL PALSY

Nabiyeva Nozima Abdurakhimovna Bukhara State Medical Institute

Resume

Introduction. Cerebral palsy (CP) is one of the main causes of childhood disability. The addition of symptomatic epilepsy (SE) aggravates the process. Patients with cerebral palsy are a group with combined damage to the nervous and immune systems. Products from an activated immune system can generate a feedback signal that can inhibit, enhance, or regulate neuronal activity.

Materials and methods. We investigated the level of pro-inflammatory (TNFα, IFNγ) and anti-inflammatory (IL-10) cytokines in the serum of peripheral blood and cerebrospinal fluid (CSF) of three groups (30 persons in each): with cerebral palsy, with SE associated with cerebral palsy and control (norm). The studies were carried out in the laboratory of immunomorphology of the Institute of Immunology of the Academy of Sciences of the Republic of Uzbekistan. The concentration of cytokines – interleukin-10 (IL-10), interferon γ (IFNγ) and tumor necrosis factor (TNFα) – was determined by enzyme-linked immunosorbent assay using reagents of LLC “Cytokine” of St.Petersburg Research Institute of Highly Pure Biological Products.

Results and its discussion. The content of TNFα in the serum of peripheral blood in children with cerebral palsy increased the control values by 3 times. With the addition of epilepsy, the cytokine content increases and significantly increases the control by 4.1 times, and the indicator of cerebral palsy alone – 1.3 times. In CSF, the level of IFN-γ was even more higher than the control: 3.5 and 4.4 times, respectively, with and without SE. Determination of the content of IL-10 in CSF showed its significant excess over the control – 2.5 and 3.3 times, respectively.

Conclusion. High levels of IL-10 enhances the epileptic activity of the brain. The presence of an immune response tension in conditions of massive antigenic stimulation already in early childhood is determined by an increase in the level of pro-inflammatory cytokines in sick children.

Keywords: children cerebral palsy, epilepsy, immunity, citokines, plasma, cerebro-spinal fluid

First page

300

Last page

304

For citation: Nabiyeva Nozima Abdurakhimovna NEUROIMMUNE INTERACTIONS AND CYTOKINE LEVELS IN CHILDREN WITH CEREBRAL PALSY //New Day in Medicine 3(35)2021 https://cutt.ly/mEOxyGY

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