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  • 84 -4 (66) 2024 - Ubaydullaev S.A., Alyavi A.L. - ENDOTHELIAL DYSFUNCTION AFTER COVID-19 IN PATIENTS WITH CORONARY ARTERY DISEASE ON THE BACKGROUND OF DIABETES

84 -4 (66) 2024 - Ubaydullaev S.A., Alyavi A.L. - ENDOTHELIAL DYSFUNCTION AFTER COVID-19 IN PATIENTS WITH CORONARY ARTERY DISEASE ON THE BACKGROUND OF DIABETES

ENDOTHELIAL DYSFUNCTION AFTER COVID-19 IN PATIENTS WITH CORONARY ARTERY DISEASE ON THE BACKGROUND OF DIABETES

Ubaydullaev S.A. Republican Specialized Scientific Practical Medical Center of Therapy and Medical Rehabilitation, Tashkent, Uzbekistan

Alyavi A.L. Republican Specialized Scientific Practical Medical Center of Therapy and Medical Rehabilitation, Tashkent, Uzbekistan

Ubaydullaeva Sh.M. Republican Specialized Scientific Practical Medical Center of Therapy and Medical Rehabilitation, Tashkent, Uzbekistan

Latipov N.M. Republican Specialized Scientific Practical Medical Center of Therapy and Medical Rehabilitation, Tashkent, Uzbekistan

Resume

The COVID-19 pandemic has had a significant impact on global health, prompting an urgent need to study its effects on people with chronic diseases. Particularly, the consequences of COVID-19 for patients with coronary artery disease (CAD) and diabetes, who are at an especially high risk of developing cardiovascular complications, have become a critical area of research. An important aspect of the interaction between these conditions is endothelial function, which plays a key role in maintaining vascular health and regulating blood flow. This review is dedicated to analyzing endothelial function disturbances following COVID-19 infection in patients with CAD and diabetes. The article discusses the mechanisms of SARS-CoV-2's impact on the endothelium, including direct viral damage to endothelial cells and induced inflammation, oxidative stress, and hypercoagulability, which can exacerbate endothelial dysfunction in this patient category. Methods for assessing endothelial function, from non-invasive ultrasound studies to invasive tests, their advantages, and limitations in the context of post-COVID research are reviewed. Special attention is given to therapeutic strategies and perspectives on managing endothelial dysfunction, incorporating both pharmacological and non-pharmacological approaches aimed at improving vascular health and preventing long-term cardiovascular complications. The conclusion emphasizes the need for further research to better understand the long-term impact of COVID-19 on endothelial function in patients with CAD and diabetes. It highlights the importance of developing targeted therapeutic strategies capable of minimizing the negative consequences of COVID-19 and improving the prognosis for this vulnerable group of patients.

Keywords:COVID-19, endothelial function, coronary artery disease, diabetes, endothelial dysfunction.

First page

476

Last page

484

For citation: Ubaydullaev S.A., Alyavi A.L., Ubaydullaeva Sh.M., Latipov N.M. - ENDOTHELIAL DYSFUNCTION AFTER COVID-19 IN PATIENTS WITH CORONARY ARTERY DISEASE ON THE BACKGROUND OF DIABETES//New Day in Medicine 4(66)2024 476-484 https://newdayworldmedicine.com/en/article/3758

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