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64 -3 (35) 2021 — Ergashov Bobir Bakhodirovich, Abdullaeva Umida Kurbanovna — MODERN CONCEPT OF CLINIC AND DIAGNOSIS OF CARDIOVASCULAR COMPLICATIONS IN CHEMOTHERAPY

MODERN CONCEPT OF CLINIC AND DIAGNOSIS OF CARDIOVASCULAR COMPLICATIONS IN CHEMOTHERAPY

Ergashov Bobir Bakhodirovich, Bukhara State Medical Institute, Bukhara, Uzbekistan

Abdullaeva Umida Kurbanovna Bukhara State Medical Institute, Bukhara, Uzbekistan

Resume

The given review is devoted to the problem of the cardiotoxicity of chemotherapeutic agents. Many of chemotherapeutic agents can cause cardiovascular complications such as left ventricular dysfunction and heart failure development, myocardial ischemia, arterial hypertension, thromboembolism, QT prolongation and arrhythmias. The toxic influence of the most often used chemotherapeutic agents on heart (such as antimetabolites, alkylating agents, platinum compounds, taxanes, vinca alkaloids, monoclonal antibodies, anthracycline antibiotics, topoisomerase and protein kinase inhibitors, immunomodulatory agents and cytokines) has been described. The results of recent studies on etiology, pathogenesis and clinical features of chemotherapy-induced cardiotoxicity were present in the first part of review. The clinical features, diagnosis, treatment and prevention of the cardiotoxicity of chemotherapeutic agents, are described in the second part of the review

Keywords: chemotherapy; cardiotoxicity; pathogenesis; drug-induced cardiomyopathy.

First page

318

Last page

321

For citation: Ergashov Bobir Bakhodirovich, Abdullaeva Umida Kurbanovna MODERN CONCEPT OF CLINIC AND DIAGNOSIS OF CARDIOVASCULAR COMPLICATIONS IN CHEMOTHERAPY //New Day in Medicine 3(35)2021 318-321 https://cutt.ly/3EOxFwB

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