2 -5 (67) 2024 - Sadikova N.G., Najmutdinova D.K. - THE ROLE OF ALLELIC AND GENOTYPIC VARIANTS OF THE ALA16VAL POLYMORPHISM OF THE SOD2 GENE IN THE DEVELOPMENT OF THE CARDIOVASCULAR FORM OF DIABETIC AUTONOMIC NEUROPATHY IN PATIENTS WITH TYPE

THE ROLE OF ALLELIC AND GENOTYPIC VARIANTS OF THE ALA16VAL POLYMORPHISM OF THE SOD2 GENE IN THE DEVELOPMENT OF THE CARDIOVASCULAR FORM OF DIABETIC AUTONOMIC NEUROPATHY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Sadikova N.G. Tashkent Medical Academy

Najmutdinova D.K. Tashkent Medical Academy

Boboev K.T. Tashkent Medical Academy

Resume

This article analyzes allelic and genotypic variants of the Ala16Val polymorphism of the SOD 2 gene in the development of the cardiovascular form of diabetic autonomic neuropathy in patients with type 2 diabetes mellitus. 135 patients with type 2 diabetes mellitus (type 2 DM) were studied. All patients using Holter monitoring were divided into two groups. The first group consisted of patients with type 2 diabetes and cardiovascular form of diabetic autonomic neuropathy (DAN+) and the second group without this complication (DAN-). All patients underwent molecular genetic studies of the Ala16Val polymorphism of the SOD2 gene and the influence of this gene in the development of cardiovascular DAN. As the results of our study showed, this gene plays an important role in the development of cardiovascular form of DAN in patients with type 2 diabetes.

Keywords: diabetes mellitus type 2, diabetic autonomic neuropathy, cardiovascular form, polymorphism of the superoxide dismutase gene.

First page

10

Last page

15

For citation: Sadikova N.G., Najmutdinova D.K., Boboev K.T. - THE ROLE OF ALLELIC AND GENOTYPIC VARIANTS OF THE ALA16VAL POLYMORPHISM OF THE SOD2 GENE IN THE DEVELOPMENT OF THE CARDIOVASCULAR FORM OF DIABETIC AUTONOMIC NEUROPATHY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS//New Day in Medicine 5(67)2024 10-15 https://newdayworldmedicine.com/en/article/3758

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