140 -4 (66) 2024 - Khamdamov B.Z., Nurov U.I. - THE EFFECTIVENESS OF BRONCHO-MUNAL IN THE CORRECTION OF CYTOKINE STATUS IN PATIENTS WITH CHRONIC SUPPURATIVE OTITIS MEDIA
THE EFFECTIVENESS OF BRONCHO-MUNAL IN THE CORRECTION OF CYTOKINE STATUS IN PATIENTS WITH CHRONIC SUPPURATIVE OTITIS MEDIA
Khamdamov B.Z. Bukhara State Medical Institute named after Abu Ali ibn Sina
Nurov U.I. Bukhara State Medical Institute named after Abu Ali ibn Sina
Uktamov I.G. Bukhara State Medical Institute named after Abu Ali ibn Sina
Resume
The effectiveness of standard and combined treatment using broncho-munal therapy was evaluated based on the study of the levels of interleukin-2, interleukin-6 and tumor necrosis factor in 84 patients with chronic purulent otitis media. Broncho-munal 7mg was administered every day morning for 10days. Such a 10-day cure was returned for 3 months and, as far as possible, an attempt was made to correct it to those days of the month when the drug was taken. It was found that by the end of the course of traditional therapy, a cytokine imbalance persists, indicating ongoing inflammatory changes. The inclusion of broncho-munal in the treatment regimen of patients with chronic suppurative otitis media significantly improved cytokine status.
Keywords: cellular and humoral immunity, broncho-munal, chronic suppurative otitis media
First page
772
Last page
776
For citation: Khamdamov B.Z., Nurov U.I., Uktamov I.G. - THE EFFECTIVENESS OF BRONCHO-MUNAL IN THE CORRECTION OF CYTOKINE STATUS IN PATIENTS WITH CHRONIC SUPPURATIVE OTITIS MEDIA//New Day in Medicine 4(66)2024 772-776 https://newdayworldmedicine.com/en/article/3758
List of References
- Crawford DC, Akey DT, Nickerson DA. The patterns of natural variation in human genes. Annual Review of Genomics and Human Genetics. 2005;25(6):287-312. DOI: 10.1146/annurev.genom.6.080604.162309.
- Seminsky IZH, Mayboroda AA. Features of cellular reactions in foci of inflammation of different etiology. Message 4. Factors, mechanisms and criteria of chronic inflammation. Journal of Infectious Pathology. 2000;7(3-4):33-8. [Seminskij IZh, Majboroda AA. Features cellular responses in areas of inflammation of different etiology. Message 4. Factors, mechanisms and criteria for chronic inflammation. Zhurnal Infekcionnoj Patologii. 2000;7(3-4):33-8. ( In Russian)]
- Vitkovsky UA, Kuznik BI, Solpov AV, Gvozdeva O.V., Rodnina OS. The state of immunity and lymphocytic-platelet adhesion in diffuse toxic goiter. Medical immunology. 2010;12(1-2):133-8. DOI: 10.15789/1563-0625-2010-1-2-133-138.
- Vitkovskij YuA, Kuznik BI, Solpov AV, Gvozdeva OV, Rodnina OS Immunity and lymphocyte-platelet adhesion in diffuse toxic goiter. //Medical Immunology. 2010;12(1-2):133-8. (In Russian)]
- Kuznik BI, Solpov A, Magen E. Lymphocyte-platelet crosstalk in grayes’ disease. //American Journal of the Medical Sciences. 2014;347(3):206-10. DOI: 10.1097/maj.0b013e3182831726
- Lyubin AV, Solpov AV, Shapovalov KG. platelet aggregation. Far Eastern Medical Journal. 2012(1):112. [Lyubin AV, Solpov AV, SHapovalov KG. Aggregation of thrombocytes. Far East Medical Journal. 2012;(1):112. (In Russian)]
- Vitkovsky, Yu.A., Kuznik B.I., Solpov A.V. Results of a 10-year study of the mechanisms of lymphocytic-platelet adhesion. Zabaikalsky Medical Bulletin. 2008;(2):36-41. [Vitkovskij YuA, Kuznik BI, Solpov AV. Results of the 10-year study of mechanisms of lymphocyte-platelet adhesion. //The Transbaikalian Medical Bulletin. 2008;(2):36-41. (In Russian)]
- Li N, Ji Q, Hjemdahl P. Platelet-lymphocyte conjugation differ between lymphocyte subpopulation. //Thrombosis and Haemostasis. 2006;(4):874-881. DOI: doi.org/10.1111/j.1538-7836.2006.01817.
- Sigal A, Bleijs DA, Grabovsky V. The LFA-1 integrin supports rolling adhesion on ICAM-1 under physiological shear flow in a permissive cellular environment. Immunology. 2000;165(1):442-542.DOI: 10.4049/jimmunol.165.1.442.
- Hawrylowich CM, Howells GL, Feldmann M. Platelet-derived interleukin-1 induces human endothelial adhesion molecule expression and cytokine production. //Journal of Experimental Medicine. 1991;174(4):785 90.DOI: 10.1084/jem.174.4.785.
- Solpov A, Shenkman B, Vitkovsky Y, Brill G, Koltakov A, Farzam N, Varon D, Bank I, Savion N. Platelets enhance CD4+ lymphocyte adhesion to extracellular matrix under flow conditions: Role of platelet aggregation, integrins,and non-integrin receptors. //Thrombosis and Haemostasis. 2006;95(5):815-21.DOI: 10.1160/th05-07-0524.
- Brandt E, Ludwig A, Peterson F, Flad HD. Platelet-derived CXC chemokines: old players in new games. //Immunology Reviews. 2000;(17):204-16.DOI:10.1034/j.1600-065x.2000.17705.
- Dudek A, Nesmelova I, Majo K. Platelet factor 4 promotes adhesion of hematopoietic progenitor cells and binds IL-8. Blood. 2003;101(12):4687-92. DOI: 10.1182/blood-2002-08-2363
- Weyrich AS, Zimmerman GA. Platelets: signaling cells in the immune continuum. //Trends of Immunology. 2004;25(9):489-95. DOI: 10.1016/j.it.2004.07.003
- Solpov AV, Kuznik BI, Vitkovskij YuA, Yedelev D.Influence of interleukin 4 and 10 on haemostasis. //Thrombosis and Haemostasis. Abstr. XVII Congress of the ISTH, Washington D.C., August 14-21. 1999;(34):110. DOI:10.1016/s0248-8663(00)87076-9
- Browder T, Folkman J, Pirie-Shepherd S. The haemostatic system as a regulator of angiogenesis. //The Journal of Biological Chemistry. 2000;275(3):1521-4. DOI:10.1074/jbc.275.3.1521
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