158 -5 (67) 2024 - Shukurova D.Yu., Khamidullaeva G.A. - STUDY OF ADHERENCE TO THREE-COMPONENT ANTIHYPERTENSIVE THERAPY IN PATIENTS WITH UNCONTROLLED ARTERIAL HYPERTENSION

STUDY OF ADHERENCE TO THREE-COMPONENT ANTIHYPERTENSIVE THERAPY IN PATIENTS WITH UNCONTROLLED ARTERIAL HYPERTENSION

Shukurova D.Yu. - Republican Specialized Cardiology Scientific and Practical Medical Center

Khamidullaeva G.A. - Republican Specialized Cardiology Scientific and Practical Medical Center

Resume

The number of taken medications has been repeatedly shown to be an important factor in treatment propensity. It has been proven that adherence to treatment is 30% when taking 3 drugs, 40% when taking 4, 50% when taking 5 or more, and even 100% abstinence. Purpose of the study: to study the effectiveness of treatment compliance in patients with uncontrolled arterial hypertension (AH) who received triple antihypertensive therapy in a fixed and free combination. Material and methods: The study included 86 patients with grade 1-3 hypertension. The average age was 63.1±8.9 years. In accordance with the clinical protocol, we assessed the MMAS-8 questionnaire “8-item Morisky Medication Adherence Scale” to assess the propensity to treatment of patients. Patients received three-component antihypertensive therapy (AHT) in fixed group 1 (n=44) and group 2 (n=42) in a free combination. Results: According to our study, 10 (11.9%) patients were under 44 years old, 36 (42.8%) patients were 45-59 years old, 38 (45.2%) were 60 - 74-year-old patients. Intergroup analysis revealed no statistical differences in age between groups 1 and 2 before treatment. Before treatment, regardless of the age of the patients, on average 70% of patients had a low adherence for treatment (<5 points). At the end of follow-up, the MMAS-8 test was repeated in both groups of patients. More than 80% of patients achieved target blood pressure levels during the 24-week triple AHT. At the same time, in the young group, adherence increased by only 10%, which is significantly lower than in the middle-aged and elderly group, where adherence to therapy increased 2 or more times compared to the young. According to the results of treatment, adherence to therapy significantly increased in 1st group: 8 points in 19 (41.3%) patients, 6-7 points in 14 (30.4%), 5 or less points in 13 (28.2%) patients. In 2nd group, achieving high adherence was 2 times less: 7 (17.5%) patients scored 8 points, 7 (17.5%) scored 6-7 points, 26 (65%) patients scored ≤5 points, which is 2.5 times more than in 1st group. Conclusions: Triple AHT for 24 weeks demonstrated increased patient’s adherence, with a significant increase in adherence in middle-aged and elderly patients compared with younger patients. Patients receiving a fixed combination of 3 drugs had a significant increase in adherence to treatment compared to patients receiving a free combination.

Key words: uncontrolled arterial hypertension, antihypertensive therapy, susceptibility to treatment, 24-week therapy.

First page

896

Last page

903

For citation:Shukurova D.Yu., Khamidullaeva G.A. - STUDY OF ADHERENCE TO THREE-COMPONENT ANTIHYPERTENSIVE THERAPY IN PATIENTS WITH UNCONTROLLED ARTERIAL HYPERTENSION//New Day in Medicine 5(67)2024 896-903 https://newdayworldmedicine.com/en/article/3758

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