16 -6 (68) 2024 - Khasanova D.A., Sharipova E.M. - STUDYING STRUCTURAL CHANGES IN REGIONAL LYMPH NODES DURING EXPERIMENTAL PNEUMOSCLEROSIS IN RATS

STUDYING STRUCTURAL CHANGES IN REGIONAL LYMPH NODES DURING EXPERIMENTAL PNEUMOSCLEROSIS IN RATS

Khasanova D.A. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Sharipova E.M. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Interstitial pathology of the lungs with various manifestations is currently of interest for reasoning and the approach of new methods for the prevention and treatment of certain types of pulmonary fibrosis. Of particular interest is the study of their clinical and morphological characteristics to identify different types of fibrotic processes occurring in the lungs. The division of pulmonary fibrosis into multiple forms in the histological classification is due to differences in the mechanisms of its occurrence and course. However, changes in the lymph nodes during the fibrotic process of lung tissue have been little studied. In the article, we tried to collect literature data on structural changes in regional lymph nodes that occur against the background of pulmonary fibrosis.

Key words: pneumosclerosis, regional lymph nodes, pulmonary fibrosis in rats, literature data.

First page

86

Last page

82

For citation:Khasanova D.A., Sharipova E.M. - STUDYING STRUCTURAL CHANGES IN REGIONAL LYMPH NODES DURING EXPERIMENTAL PNEUMOSCLEROSIS IN RATS //New Day in Medicine 6(68)2024 86-92 https://newdayworldmedicine.com/en/article/3758

List of References

  1. Adegunsoye A. et al. Prognosticating Outcomes in Interstitial Lung Disease by Mediastinal Lymph Node Assessment. An Observational Cohort Study with Independent Validation. Am //J Respir Crit Care Med. 2019; 747-759. doi: 10.1164/rccm.201804-0761OC. PMID: 30216085; PMCID: PMC6423102.
  2. Annika Goorsenberg , Kirsten A Kalverda ET all. // Advances in Optical Coherence Tomography and Confocal Laser Endomicroscopy in Pulmonary Diseases 2020; 190-205. doi: 10.1159/000503261. Epub 2019 Oct 8.
  3. Behr J. et al. Exploring efficacy and safety of oral Pirfenidone for progressive, non-IPF lung fibrosis (RELIEF)-a randomized, double blind, placebo-controlled, parallel group, multi-center, phase II trial //BMC pulmonary medicine. – 2017; 1-9.
  4. Cuccurullo V, Rapa M, Catalfamo B, Cascini GL. Role of Nuclear Sentinel Lymph Node Mapping Compared to New Alternative Imaging Methods. J Pers Med. 2023 Jul 31;13(8):1219. doi: 10.3390/jpm13081219. PMID: 37623469; PMCID: PMC10455335.
  5. Cakala-Jakimowicz M, Kolodziej-Wojnar P, Puzianowska-Kuznicka M. Aging-Related Cellular, Structural and Functional Changes in the Lymph Nodes: A Significant Component of Immunosenescence? An Overview. Cells. 2021 Nov 12;10(11):3148. doi: 10.3390/cells10113148. PMID: 34831371; PMCID: PMC8621398.
  6. Fox S. E. et all. Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans //The Lancet Respiratory Medicine. – 2020. – Т. 8. – №. 7. – С. 681-686.
  7. Grecuccio S. et all. Prognostic value of mediastinal lymph node enlargement in chronic interstitial lung disease. Diagn Interv Radiol. 2021 May;27(3):329-335. doi: 10.5152/dir.2021.19585. PMID: 34003121; PMCID: PMC8136534.
  8. Karampitsakos T. et all. Expression of PD-1/PD-L1 axis in mediastinal lymph nodes and lung tissue of human and experimental lung fibrosis indicates a potential therapeutic target for idiopathic pulmonary fibrosis. Respir Res. 2023 Nov 14;24(1):279. doi: 10.1186/s12931-023-02551-x. PMID: 37964265; PMCID: PMC10648728.
  9. Khanna D. et al. An open-label, phase II study of the safety and tolerability of pirfenidone in patients with scleroderma-associated interstitial lung disease: the LOTUSS trial //The Journal of rheumatology. – 2016. – Т. 43. – №. 9. – С. 1672-1679.
  10. Khasanova D. A., Avezova D. B. Morphological Changes Observed in the Lungs in Chronic Renal Failure (Experiment) //International Journal of Pediatrics and Genetics. – 2023. – Т. 1. – №. 3. – С. 4-6.
  11. Liao Y.W. et all. Multidisciplinary-derived clinical score for accurate prediction of long-term mortality in fibrotic lung disease patients. Eur J Med Res. 2024 Jan 20;29(1):69. doi: 10.1186/s40001-024-01644-7. PMID: 38245785; PMCID: PMC10799536.
  12. Maher TM, Bendstrup E, Dron L, Langley J, Smith G, Khalid JM, Patel H, Kreuter M. Global incidence and prevalence of idiopathic pulmonary fibrosis. Respir Res. 2021 Jul 7;22(1):197. doi: 10.1186/s12931-021-01791-z. PMID: 34233665; PMCID: PMC8261998.
  13. Mohammadi A. et al. Post-COVID-19 pulmonary fibrosis //Cureus. – 2022. – Т. 14. – №. 3.
  14. Pan J, Li X. et al. MCTR1 Intervention Reverses Experimental Lung Fibrosis in Mice. J Inflamm Res. 2021 May 11;14:1873-1881. doi: 10.2147/JIR.S304811. PMID: 34007201; PMCID: PMC8123946.
  15. Tan J, Xue Q, Hu X, Yang J. Inhibitor of PD-1/PD-L1: a new approach may be beneficial for the treatment of idiopathic pulmonary fibrosis. J Transl Med. 2024 Jan 23;22(1):95. doi: 10.1186/s12967-024-04884-7. PMID: 38263193; PMCID: PMC10804569.
  16. Turner VM, Mabbott NA. Structural and functional changes to lymph nodes in ageing mice. Immunology. 2017 Jun;151(2):239-247. doi: 10.1111/imm.12727. Epub 2017 Mar 16. PMID: 28207940; PMCID: PMC5418465.
  17. Sgalla Giacomo et all. /Mediastinal lymph node enlargement in idiopathic pulmonary fibrosis: relationships with disease progression and pulmonary function trends// BMC Pulmonary Medicine, 20.249. DOI:10.1186/s12890-020-01289-2 2020 Sep 21.
  18. Sin S. et al. Impact of mediastinal lymph node enlargement on the prognosis of idiopathic pulmonary fibrosis //PLoS One. – 2018. – Т. 13. – №. 7. – С. e0201154.
  19. Spagnolo P. et al. Mechanisms of progressive fibrosis in connective tissue disease (CTD)-associated interstitial lung diseases (ILDs). Ann Rheum Dis. 2021 Feb;80(2):143-150. doi: 10.1136/annrheumdis-2020-217230. Epub 2020 Oct 9. PMID: 33037004; PMCID: PMC7815631.
  20. Suami H, Scaglioni MF. Anatomy of the Lymphatic System and the Lymphosome Concept with Reference to Lymphedema. Semin Plast Surg. 2018 Feb;32(1):5-11. doi: 10.1055/s-0038-1635118. Epub 2018 Apr 9. PMID: 29636647; PMCID: PMC5891651.

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