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  • 53 -6 (68) 2024 - Sadulloeva Iroda Kurbanovna - GENOTYPES MTR A2756G; rs1805087, MTHFR C677T; rs1801133 AND RFC1 SLC19A1 G80A; rs105126680 A/G FOR CHILDREN LIVING IN THE BUKHARA REGION

53 -6 (68) 2024 - Sadulloeva Iroda Kurbanovna - GENOTYPES MTR A2756G; rs1805087, MTHFR C677T; rs1801133 AND RFC1 SLC19A1 G80A; rs105126680 A/G FOR CHILDREN LIVING IN THE BUKHARA REGION

GENOTYPES MTR A2756G; rs1805087, MTHFR C677T; rs1801133 AND RFC1 SLC19A1 G80A; rs105126680 A/G FOR CHILDREN LIVING IN THE BUKHARA REGION

Sadulloeva Iroda Kurbanovna - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Congenital heart defects (CHD) are one of the leading causes of disability in young children, as well as the cause of early mortality. In the pathogenesis of the development of CHD, we should talk about a combination of social, hereditary, medical factors, as well as environmental factors. In the study group of children with CHD such as TF, DMF and DMPP, significant differences in the frequency of occurrence of allelic variants and genotypic combinations of the genes MTR A2756G; rs1805087, MTHFR C677T; rs1801133 were revealed. At the same time, the RFC1 SLC19A1 G80A; rs105126680 A/G marker did not show significant differences in our sample. Congenital heart defects are positively associated with the genotype MTR A2756G; rs1805087 A/G and G/G and MTHFR C677T; rs1801133 T/T polymorphic variants of folate cycle genes.

Key words: Congenital heart defects, children, MTR a2756g, rs1805087, MTHFR S677T, rs1801133, RFS1 SLS19A1 G80A, gene polymorphism, genotype

First page

313

Last page

319

For citation:Sadulloeva Iroda Kurbanovna - GENOTYPES MTR A2756G; rs1805087, MTHFR C677T; rs1801133 AND RFC1 SLC19A1 G80A; rs105126680 A/G FOR CHILDREN LIVING IN THE BUKHARA REGION//New Day in Medicine 6(68)2024 313-319 https://newdayworldmedicine.com/en/article/3758

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