5 -7 (69) 2024 - Azizov D.T., Mirzaev K.K. - FEATURES OF CHANGES IN BLOOD OF CYTOKINES AND PROTEASE INHIBITORS IN PATIENTS WITH LONG-HEALING PURULENT WOUNDS

FEATURES OF CHANGES IN BLOOD OF CYTOKINES AND PROTEASE INHIBITORS IN PATIENTS WITH LONG-HEALING PURULENT WOUNDS

Azizov D.T. - Andijan State Medical Institute

Mirzaev K.K. - Andijan State Medical Institute

Aleinik V.A. - Andijan State Medical Institute

Babich S.M. - Andijan State Medical Institute

Resume

The aim of the study was to study the dynamics of changes in cytokines and protease inhibitors in patients with long-healing purulent wounds from 1 to 30 days after injury. The following results were obtained: In patients with long-healing purulent wounds, on the first day after injury, more pronounced manifestations of pro-inflammatory immune factors were noted in the blood serum compared to short-healing clean wounds, which may contribute to the risk of developing long-healing purulent wounds. In patients with long-healing purulent wounds, on the 3rd day after injury, more pronounced manifestations of pro-inflammatory immune factors were observed in the blood compared to patients with short-healing clean wounds, which is a consequence of the increased immune response in the patient and is a risk of a long-healing purulent process. On day 7, patients with short-healing clean wounds showed restoration of the pro-inflammatory immune response and wound healing. In patients with long-healing purulent wounds, on the 15th day there was no significant initial recovery, but on the 30th day there was a complete restoration of immune reactions and wound healing.

Keywords: Pro-inflammatory interleukins, anti-inflammatory interleukins, protease inhibitors, long-term healing purulent wounds, short-healing clean wounds.

First page

26

Last page

33

For citation:Azizov D.T., Mirzaev K.K., Aleinik V.A., Babich S.M. - FEATURES OF CHANGES IN BLOOD OF CYTOKINES AND PROTEASE INHIBITORS IN PATIENTS WITH LONG-HEALING PURULENT WOUNDS//New Day in Medicine 7(69)2024 26-33 https://newdayworldmedicine.com/en/new_day_medicine/7-69-2024

List of References

1. Кубышкин В. А., Самоходская Л. М., Королев Ю. М. Роль маркеров системного воспалительного ответа в послеоперационном периоде. Обзор //Хирургическая практика. 2021;1:30-38.
2. Намоконов, Е. В., Герасимов, А. А. Прогнозирование течения воспалительного процесса в послеоперационном периоде при открытых переломах конечностей //Дальневосточный медицинский журнал. 2008;3:37-39.
3. Giakoumelou, S., Wheelhouse, N., Cuschieri, K., Entrican, G., Howie, S. E., & Horne, A. W. The role of infection in miscarriage //Human reproduction update. 2016;22(1):116-133.
4. Hahm G., Glaser J. J., Elster E. A. Biomarkers to predict wound healing: the future of complex war wound management //Plastic and reconstructive surgery. 2011;127:21S-26S.
5. Hawksworth J. S., Stojadinovic A., Gage F. A., Tadaki D. K., Perdue P. W., Forsberg J., Elster, E. A. Inflammatory biomarkers in combat wound healing //Annals of surgery. 2009;250(6):1002-1007.
6. Lagoutte N., Facy O., Ravoire A., Chalumeau C., Jonval L., Rat P., Ortega-Deballon P. C-reactive protein and procalcitonin for the early detection of anastomotic leakage after elective colorectal surgery: pilot study in 100 patients //Journal of visceral surgery. 2012;149(5):e345-e349.
7. Larouche J., Sheoran S., Maruyama K., Martino M.M. Immune regulation of skin wound healing: mechanisms and novel therapeutic targets //Advances in wound care. 2018;7(7):209-231.
8. Lindley L. E., Stojadinovic O., Pastar I., Tomic-Canic M. Biology and Biomarkers for Wound Healing //Plastic and Reconstructive Surgery. 2016;138(3):18-28.

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